MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactic acid , branched-chain oxo acids derived from leucine , valine , and isoleucine , and the ketone bodies acetoacetate and beta-hydroxybutyrate .

MCT2 has also been implicated as a potential biomarker in prostate cancer, selectively labeling malignant glands and improving the accuracy of diagnosis along with α-methylacyl-CoA racemase (Pertega-Gomes et al., 2013). In addition to diagnostic purposes, the role of these transporters in cancer proliferation also has identified them as a ...

1998年10月30日 · Human MCT2 is the product of a single gene that mapped to chromosome 12q13 by fluorescence in situ hybridization. The kinetic properties of human MCT2 fulfill the criteria to establish it as a H+/monocarboxylate transporter; however, the unique biochemical feature of human MCT2 is its high affinity for the transport of pyruvate (apparent Km of ...

2020年5月15日 · Here authors show a steep dependence of human MCT2 activity on substrate concentration and show the structural basis of cooperative transport.

We have molecularly cloned and characterized a novel human monocarboxylate transporter, MCT2. The cDNA is 1,907 base pairs long and encodes a polypeptide of 478 amino acids with 12 predicted transmembrane domains. Human MCT2 is the product of a single gene that mapped to chromosome 12q13 by fluorescence in situhybridization.

Especially in cancer, MCT1, MCT2, and MCT4 are considered attractive targets to inhibit lactate shuttling and thereby interfering with tumor energy metabolism.93 For instance, the anticancer drug lonidamine is especially effective in sensitizing tumor cells to other chemotherapeutic agents and this activity can be attributed, in part, to ...

It can be considered that MCT2 represents the major neuronal transporter in the rodent brain. MCT2 protein (molecular weight, ∼40–43 kDa) is strongly expressed in the cortex, the hippocampus, and the cerebellum of the rodent brain.

MCT2 generally has a higher affinity than MCT1 for monocarboxylates, such as lactate and pyruvate, which make it an ideal candidate in targeting cancer cell metabolism.

2021年4月23日 · Monocarboxylate transporter 2 (MCT2) is the predominant monocarboxylate transporter expressed by neurons. MCT2 plays an important role in brain energy metabolism. Stroke survivors are at high risk of cognitive impairment.

2020年5月15日 · To discover how MCTs solve this fundamental aspect of intracellular monocarboxylate homeostasis in the context of multicellular organisms, we analyzed pyruvate transport activity of human monocarboxylate transporter 2 (MCT2).