MLK3英文全名为Mixed Lineage Kinase 3 ，中文名为混合谱系酶3，是一个分子量为97kDa的丝氨酸/苏氨酸蛋白激酶，属 丝裂原活化蛋白激酶 (MAP3K)。 MLK3由一个SH3结构域，一个激酶 …

Martin Luther King III (born October 23, 1957) is an American human rights activist, philanthropist, and an advocate. The elder son of civil rights leaders Martin Luther King Jr. and Coretta Scott …

Mixed lineage kinase 3 (MLK3) is a serine/threonine kinase family member of mitogen activated protein kinase kinase kinases (MAP3Ks). MLK3 has been implicated in the regulation of tumor …

2022年10月1日 · Mixed lineage kinase 3 (MLK3) is a serine/threonine kinase family member of mitogen activated protein kinase kinase kinases (MAP3Ks). MLK3 has been implicated in the …

Mixed-lineage protein kinase 3 (MLK3) is a member of the mitogen-activated protein (MAP) kinase kinase kinase group that has been implicated in multiple signaling cascades, including …

2023年9月5日 · In this review, we will focus on the role of MLK3 in neuron-related cell death processes, neurodegenerative diseases, and the potential advantages of targeting this kinase …

2024年6月10日 · Mixed Lineage Kinase 3 (MLK3) is a key regulator of liver diseases, although its role in HCC remains unclear. Analysis of TCGA databases suggested elevated MAP3K11...

2020年4月7日 · Mixed lineage kinase 3 (MLK3), also known as MAP3K11, was initially identified in a megakaryocytic cell line and is an emerging therapeutic target in cancer, yet its role in …

2002年9月1日 · The MLK3 SH3 domain seems to bind intramolecularly to a region between the leucine zipper and the CRIB motif, and mutation of the single proline here prevents SH3 …

Recent advances have shown that MLK3 plays a role in cancer cell survival, migration, drug resistance, cell death, and tumor immunity. This review describes how MLK3 regulates …