2024年12月25日 · MT2A (Metallothionein 2A) is a Protein Coding gene. Diseases associated with MT2A include Scrapie and Immunodeficiency 48 . Among its related pathways are Metal ion SLC transporters and Antiviral mechanism by IFN-stimulated genes .

Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene. [3] [4] The single-nucleotide polymorphism rs28366003 which substitutes guanine for adenine in MT2A is associated with certain cancers and some chronic diseases. [5]

Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation.

2016年9月6日 · Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation.

MT2A Promotes Oxaliplatin Resistance in Colorectal Cancer Cells. Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions. MT2A is an early predictive biomarker of response to chemotherapy and a …

2015年10月12日 · Metallothionein 2A (MT2A) was identified as an interaction protein with HMBOX1 by yeast two-hybrid assay and confirmed by co-immunoprecipitation. Overexpression of HMBOX1 elevated intracellular...

2016年9月6日 · Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation.

The expression level of metallothionein 2A (MT2A), also known as MT2, is associated with tumor types. For example, MT2A is downregulated in gastric cancer and is related to the chemotherapy sensitivity of gastric cancer cells to docetaxel . Moreover, MT2A exerts its anti-gastric cancer effect by combining with MZF1 to target NFKBIA .

2022年8月1日 · Functions of metallothionein 2A (MT2A) in bladder cancer have not been extensively explored even though metallothioneins are regarded as modulators in several biological regulations including oxidation and cancerous development. We evaluated MT2A in bladder carcinoma cells in terms of the mechanisms of regulation and the underlying functions.

2020年3月1日 · This review summarises current knowledge about these three SNPs in the MT2A gene and their associations with element concentrations in the body of healthy and diseased persons. The most investigated SNP is rs28366003 (MT2A -5 A/G).