2024年12月25日 · MUC4 (Mucin 4, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC4 include Biliary Tract Cancer and Adenosquamous Carcinoma. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.

Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. [3] Like other mucins, MUC-4 is a high-molecular weight glycoprotein. [4] The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These ...

该基因编码在细胞表面发现的一种完整的膜糖蛋白，尽管可能存在分泌的同种型。 至少已经发现了该基因的两打转录本变体，尽管其中许多的全长转录本尚未确定，或者它们仅在肿瘤组织中发现。 该基因在编码序列中包含一个区域，该区域具有可变数量 (>100) 的 48 nt 串联重复。 [RefSeq 提供，2008 年 7 月] The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins …

MUC4, a member of transmembrane mucin family, is expressed in airway epithelial cells and body fluids like saliva, tear film, ear fluid, and breast milk. In addition to its normal expression, an aberrant expression of MUC4 has been reported in a variety of carcinomas.

MUC4 imparting resistance to pancreatic cancer cells against gemcitabine through the activation of anti-apoptotic pathways and, thereby, promoting cell survival. MUC4 is a lineage marker in benign cervical tissue that may have aberrant expression in squamous dysplasia and carcinoma

2021年12月9日 · We developed a method to produce and purify multi-milligram amounts of recombinant MUC4β (rMUC4β). Purified rMUC4β was characterized by Far-UV CD and I-TASSER-based protein structure prediction...

Studies on the rat homologue, Muc4, indicate that it acts through anti-adhesive or signaling mechanisms. In particular, Muc4/MUC4 can serve as a ligand/modulator of the receptor tyrosine kinase ErbB2, regulating its phosphorylation and the phosphorylation of its partner ErbB3, with or without the involvement of the ErbB3 ligand neuregulin.

2017年9月11日 · Mucin-4 (Muc4) is a large cell surface glycoprotein, composed of a heavily O-glycosylated extracellular alpha subunit and a membrane-anchored beta subunit that normally functions to...

2007年6月26日 · MUC4 is a type-1 transmembrane glycoprotein and is overexpressed in many carcinomas. It is a heterodimeric protein of 930 kDa, composed of a mucin-type subunit, MUC4 α, and a membrane-bound...

MUC4, a member of transmembrane mucin family, is expressed in airway epithelial cells and body fluids like saliva, tear film, ear fluid, and breast milk. In addition to its normal expression, an aberrant expression of MUC4 has been reported in a variety of carcinomas.