2025年2月10日 · MAEA was found to impair the proliferation and chemoresistance of GIC tumors in vitro and in subcutaneous xenograft model systems. The combination of MAEA and the PARP1 inhibitor veliparib resulted in enhanced oxaliplatin treatment efficacy in vivo.

6 天之前 · The IAEA is the world's centre for cooperation in the nuclear field, promoting the safe, secure and peaceful use of nuclear technology. It works in a wide range of areas including energy generation, health, food and agriculture and environmental protection.

2024年12月25日 · MAEA (Macrophage Erythroblast Attacher, E3 Ubiquitin Ligase) is a Protein Coding gene. Diseases associated with MAEA include Schizophrenia 16 and Schizophrenia 15. Among its related pathways are Regulation of pyruvate metabolism and Respiratory electron transport. Gene Ontology (GO) annotations related to this gene include actin binding.

2021年5月4日 · Here, we report that Macrophage-Erythroblast Attacher (MAEA, also known as EMP), a receptor thus far only identified in erythroblastic island, is a membrane-associated E3 ubiquitin...

2025年2月9日 · Gene ID: 10296, updated on 9-Feb-2025. This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis.

Macrophage-Erythroblast Attacher (Maea) was originally identified as an adhesion molecule required for erythroblastic island (EI) formation by homophilic interaction between macrophage and erythroblast.

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed: 29911972).

该基因编码的蛋白质介导成红细胞与巨噬细胞的结合。 这种附着促进成红细胞的终末成熟和去核，可能是通过抑制细胞凋亡。 所编码的蛋白质是一种完整的膜蛋白，其 N 端位于细胞外侧，C 端位于细胞质侧。 可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 7 月] This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing …

2021年5月4日 · Here, we report that Macrophage-Erythroblast Attacher (MAEA, also known as EMP), a receptor thus far only identified in erythroblastic island, is a membrane-associated E3 ubiquitin ligase subunit essential for HSC maintenance and lymphoid potential.

MAEA mediates attachment of erythroblasts to macrophages (Hanspal et al., 1998). Hanspal et al. (1998) cloned an MAEA cDNA from a human macrophage cDNA expression library using antibody to the purified protein as probe.