Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene. [5][6] The protein encoded by this gene belongs to the Bcl-2 family. …

2021年9月2日 · MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer...

2024年12月25日 · MCL1 (MCL1 Apoptosis Regulator, BCL2 Family Member) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Hematologic Cancer. …

MCL1 凋亡调节因子，BCL2 家族成员： 该基因编码一种抗凋亡蛋白，它是 Bcl-2 家族的一员。 可变剪接导致多个转录本变体。 最长的基因产物 (异构体 1) 通过抑制细胞凋亡增强细胞存活， …

因此，靶向MCL-1抗凋亡蛋白抑制剂的研发对肿瘤的治疗具有独特的意义，已经成为抗肿瘤药物研究的热点之一。 1. MCL-1的生物学功能. 2. MCL-1与血液恶性肿瘤. 3. MCL-1抑制剂靶向治疗 …

Myeloid cell leukemia-1 (MCL1), an antiapoptotic member of the BCL2 family characterized by a short half-life, functions as a rapid sensor that regulates cell death and other relevant …

Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is …

2020年1月6日 · Mcl-1 is a short-lived protein, which renders it highly sensitive to changes in its synthesis or degradation. Targeting regulatory circuits that control Mcl-1 level could provide a …

5 天之前 · However, due to the unsolved cardiotoxicity associated with direct MCL1 inhibitors, finding combinations of agents that indirectly target MCL1 and enable the reduction of doses …

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control, promoting cell survival by interfering at an early stage in a cascade of events leading to release of …