2022年7月6日 · I've been getting positive ANA results since 2014 - in 2014 they were 1:1280 speckled, in 2016 they were 1:640 speckled, and in 2022 they were 1:1280 nuclear speckled (AC-2,4,5,29) and mitotic spindle fibers (AC-25).

In a properly formed mitotic spindle, bi-oriented chromosomes are aligned along the equator of the cell with spindle microtubules oriented roughly perpendicular to the chromosomes, their plus-ends embedded in kinetochores and their minus-ends anchored at the cell poles.

2023年2月17日 · Spindle fibers are a network of filaments called microtubules that move chromosomes during eukaryotic cell division. Spindle fibers formed in mitosis are called the mitotic spindle, while those formed in meiosis are called the meiotic spindle. Microtubules that form the spindle fibers come from centrosomes. Spindle fibers play a significant ...

2020年11月18日 · Spindle fibers are microscopic protein structures that help divide genetic material during cell division and organize cellular components. The spindle fibers form out of the centrosome, also known as the microtubule-organizing center, or MTOC.

2021年3月1日 · The spindle apparatus that forms during mitosis is referred to as mitotic spindle whereas the one that forms during meiosis is called meiotic spindle. Spindle fibers are made up of microtubules and they appear as spindle-shaped structures (thus, the name).

These interpolar bundles, termed bridging fibers, balance the forces acting at kinetochores and support the rounded shape of the spindle during metaphase. This review discusses the structure, function, and formation of kinetochore fibers and interpolar …

2019年11月11日 · In animal cells, a mitotic spindle appears as asters that surround each centriole pair. The cell becomes elongated as spindle fibers stretch from each pole. Sister chromatids attach to spindle fibers at their kinetochores.

Upon describing the basic spindle anatomy and defining its constituents, we first discuss bulk and single-molecule methods that have allowed inference of the dynamic behavior and organizations of MTs within the metaphase spindle and the principles …

During mitosis, the spindle fibers are called the mitotic spindle. Meanwhile, during meiosis, the spindle fibers are referred to as the meiotic spindle.

Spindle fibres constitute mitotic and meiotic spindle during cell division. They are formed by microtubules and play an important role during nuclear division. They are responsible for the segregation of sister chromatids and movement of chromosomes during …