2024年12月25日 · MNX1 (Motor Neuron And Pancreas Homeobox 1) is a Protein Coding gene. Diseases associated with MNX1 include Currarino Syndrome and Neonatal Diabetes. Among its related pathways is Neural Stem Cells and Lineage-specific Markers.

MNX1 plays an indispensable role in promoting of human CRC progression. MNX1-AS1 promoted the proliferation, migration, and invasion of GBM cells through inhibiting miR-4443. MNX1 may directly regulate TrkB expression, which may increase their metastatic potential via suppression of anoikis and enhanced adhesion to the ECM.

2025年2月6日 · MNX1 ablation activates cytotoxic T cell-mediated anti-tumor immunity and sensitizes CTLA-4 blockade therapy. Moreover, MNX1 also facilitates tumor progression in an immune-independent manner in cancer cells.

2025年2月6日 · MNX1 ablation activates cytotoxic T cell-mediated anti-tumor immunity and sensitizes CTLA-4 blockade therapy. Moreover, MNX1 also facilitates tumor progression in an immune-independent manner in cancer cells.

2024年11月18日 · Long noncoding RNA MNX1-AS1 functions as a competing endogenous RNA to regulate epithelial-mesenchymal transition by sponging MiR-744-5p in colorectal cancer.

It encodes a nuclear protein named motor neuron and pancreas homeobox 1 (MNX1), also known as HLXB9 or HB9, which is a transcription factor. 3 MNX1 is a key developmental gene that is normally expressed in neurons as well as pancreatic and lymphoid cells.

Heterozygous mutations in MNX1 (also known as HLXB9) have been identified in nearly all cases of familial Currarino syndrome and in ~30% of sporadic cases (1). Molecular Genetics: The MNX1 gene is expressed during embryonic development in the basal plate of the spinal cord, hindbrain, pharynx, esophagus, stomach and pancreas (2).

Our work emphasizes the vital importance of Mnx1 for β cell development, and suggests that identifying Mnx1 transcriptional targets in β cell precursors may provide important new information of direct relevance to stem cell-based protocols to cure diabetes.

MNX1 - motor neuron and pancreas homeobox 1 Synonym(s): HB9, HOXHB9, SCRA1 Previous symbol(s) and name(s): HLXB9, homeo box HB9, homeobox HB9

2025年2月11日 · Mnx1, a gene that is absolutely required in pancreas progenitors, is a major direct target of Ptf1a and is regulated by a distant enhancer element. This study suggested that Hb9 interneurons are part of the sensorimotor circuitry that regulates the pattern of locomotor rhythms in the isolated cord.