Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene. [5] [6]

The MSLN gene is located at 16p13.3 and encodes for the MSLN mRNA. The pre-pro-mesothelin consists of a signaling peptide at the N-terminus (yellow), mature MPF (blue), furin cleavage site (red), mature mesothelin (orange), and a GPI-anchor sequence (gray).

2024年12月25日 · Complete information for MSLN gene (Protein Coding), Mesothelin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium New to GeneCards?

Since its discovery in 1992, mesothelin (MSLN) has generated significant interest as a therapeutic target. A number of characteristics make it ideal for this purpose. First, it is not expressed on the parenchyma of any vital organs.

2021年4月7日 · Mesothelin (MSLN) represents an attractive molecule for targeted cancer therapies. To identify tumors that might benefit from such therapies, tissue microarrays including 15,050 tumors from 122 different tumor types and 76 healthy organs were analyzed for MSLN expression by immunohistochemistry.

2020年12月1日 · Mesothelin (MSLN) is a lineage restricted cell surface protein expressed in about 30% of human cancers and high MSLN expression is associated with poor survival in several different cancers.

2023年7月1日 · Mesothelin (MSLN), a tumor-associated antigen, is upregulated in various malignancies, including gastric cancer (GC). In addition, MSLN is found in the blood-stream of affected individuals, where it is referred to as soluble MSLN-related protein (SMRP).

Mesothelin (MSLN) represents an attractive molecule for targeted cancer therapies. To identify tumors that might benefit from such therapies, tissue microarrays including 15,050 tumors from 122 different tumor types and 76 healthy organs were ...

2025年3月4日 · Title: Effects of hsa-mir-145-5p on the Regulation of msln Expression in Colorectal Adenocarcinoma. Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer.

2019年8月23日 · Mesothelin (MSLN), a tumor-associated antigen broadly overexpressed on various malignant tumor cells, while its expression is generally limited to normal mesothelial cells, is an attractive candidate for targeted therapy.