MTA2 is the second member of the MTA family of genes. [5] [7] [8] MTA2 protein localizes in the nucleus and is a component of the nucleosome remodeling and the deacetylation complex . [8] Similar to the founding family member MTA1, MTA2 functions as a chromatin remodeling factor and regulates gene expression.

2024年12月25日 · MTA2 (Metastasis Associated 1 Family Member 2) is a Protein Coding gene. Diseases associated with MTA2 include Cockayne Syndrome and Fanconi Anemia, Complementation Group A. Among its related pathways are RNA Polymerase I Promoter Opening and PIP3 activates AKT signaling.

该基因编码的蛋白质已被确定为 NuRD 的一个组成部分，NuRD 是一种在人类细胞核中发现的核小体重塑脱乙酰酶复合物。 它表现出非常广泛的表达模式，并在许多组织中强烈表达。 它可能代表一个小基因家族的成员，该家族编码直接或间接参与转录调控的不同但相关的蛋白质。 它们对转录调控的间接影响可能包括染色质重塑。 它与该家族的另一个成员密切相关，后者是一种与某些癌的转移潜能相关的蛋白质。 这两种蛋白质关系密切，以至于它们共享相同类型的结构域。 这些 …

2023年5月24日 · 背景：转移相关蛋白 2 (mta2) 是转移相关转录调节因子家族的成员，是核小体重塑和组蛋白脱乙酰化复合物的核心成分。 尽管越来越多的证据表明 MTA2 在某些癌症的肿瘤发生中发挥着至关重要的作用，但迄今为止还没有系统的 MTA2 泛癌分析。

MTA2 is a crucial biomarker that is closely related with prognosis of colorectal carcinoma and also a potential molecular target for evaluating the prognosis and treatment of CRC. MTA2 overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis.

MTA2, a member of the metastatic tumor-associated transcriptional regulator family, is a core component of the nucleosome remodeling and histone deacetylation complex . MTA2 is upregulated in human cancers and is associated with an aggressive phenotype, treatment resistance, and a poor prognosis in cancer patients .

2021年4月2日 · The MTA2-induced R-loop neither changed significantly with overexpressed MTA2 ΔZnF, HDAC2, or CHD4 nor was it upregulated by adding the HDAC inhibitor. These results proved that MTA2...

2023年5月24日 · Our study demonstrated that MTA2 plays crucial roles in tumor progression and tumor immunity, and it could be used as a prognostic marker for various malignancies. MK-886 might be a powerful drug for HCC.

2010年8月5日 · 已有研究发现转移相关蛋白2（metastasis-associated protein 2, MTA2）在多种肿瘤细胞系中表达且与肿瘤侵袭转移密切相关。本研究旨在研究MTA2在非小细胞肺癌（non-small cell lung cancer, NSCLC）中的表达，并探讨MTA2表达与临床病理特征的关系。

2025年2月19日 · Metastasis-Associated Protein 2 Represses NF-kappaB to Reduce Lung Tumor Growth and Inflammation. Mta2 expression is up-regulated during testicular Sertoli cells phagocytosis. Sertoli cell-specific expression of MTA2 is required for transcriptional regulation of FSHR gene during spermatogenesis.