MyoD, also known as myoblast determination protein 1, [5] is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, [6] belongs to a family of proteins known as …

2022年1月11日 · We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the establishment of MyoD ...

2024年12月25日 · MYOD1 (Myogenic Differentiation 1) is a Protein Coding gene. Diseases associated with MYOD1 include Congenital Myopathy 17 and Myopathy, Centronuclear, 1.Among its related pathways are Signaling by TGFBR3 and Signaling by TGFB family members.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity.

Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development.

MyoD is a myogenic transcription factor that belongs to the class B of bHLH proteins with a highly restricted pattern of expression limited to cells of the skeletal muscle lineage, myeloid cells of the thymus and myofibroblasts [9].

The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development. Together with the Mef2 proteins and E proteins, these transcription factors are responsible for coordinating muscle-specific gene expression in the developing embr …

肌分化因子MyoD(亦称MyoDI),是生肌调节因子(myogenic regulatory factors,MRFs)家族四成员(MyoD,MRF5,myoG,MRF4)之一,1987年首次被克隆.MyoD基因不仅可促使静止期的肌卫星细胞向成肌细胞转化,而且能把许多种类型细胞(如成纤维细胞,脂肪细胞等)转化为成肌细胞,并可促进成肌 …

MYOD is a master regulator of the skeletal myogenic program. But what regulates expression of Myod? More than 20 years ago, studies established that Myod expression is largely controlled by just two enhancer regions located within a region 24 kb upstream of …

2024年2月27日 · MyoD是一种重要的转录因子，它在肌肉细胞发育和肌肉再生中起着关键作用。MyoD蛋白质经过重组后能够在体外具有与自然形态相似的功能，因此被广泛应用于生物学研究和临床治疗领域。目录号 PA1000-8066

MyoD regulates A/B compartment switching and the forma-tion of contact domain boundaries (CDBs) in muscle cells.In light of the aforementioned MyoD data, we first performed RNA-