2024年12月25日 · NME1 (NME/NM23 Nucleoside Diphosphate Kinase 1) is a Protein Coding gene. Diseases associated with NME1 include Neuroblastoma and Neuroblastoma 1. Among its related pathways are Pyrimidine metabolism and Metabolism of nucleotides. Gene Ontology (GO) annotations related to this gene include RNA binding and GTP binding.

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. [5] . It is thought to be a metastasis suppressor. This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells.

NME1 是原型和首次描述的转移抑制基因，编码参与核苷酸代谢的核苷二磷酸激酶 (NDPK)；两个相关的家族成员 NME2 和 NME4 也被报道为转移抑制因子。 这些蛋白质与 GTP 酶动力家族的成员发生物理相互作用，后者在内吞作用和线粒体动力学所需的膜裂变和融合反应中具有关键功能。 有证据支持这样一个模型：NDPK 向动力提供 GTP，以维持局部高 GTP 浓度，从而实现最佳动力功能。 NME1 和 NME2 是胞质酶，它们为质膜上的动力蛋白提供 GTP，从而驱动内吞作用， …

NME1 was the first metastasis suppressor protein described, 1 defined as a protein with the ability to suppress the metastatic phenotype of cancer cells without having an impact on primary tumor growth.

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms.

2017年10月23日 · Several of the NME isoforms (NME1, NME5, NME7, and NME8) also exhibit a 3′–5′ exonuclease activity, suggesting roles in DNA proofreading and repair. NME1 and NME2 have been shown to translocate...

该基因和邻近的下游基因 (NME2) 的共转录产生天然存在的转录本 (NME1-NME2) ，它编码一种融合蛋白，该融合蛋白由与每个单独基因产物共享同一性的序列组成。[RefSeq 提供，2008 年 7 月] This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells ...

The metastasis suppressor protein NME1 is an evolutionarily conserved and multifunctional enzyme that plays an important role in suppressing the invasion and metastasis of tumour cells. The nucleoside diphosphate kinase (NDPK) activity of NME1 is well recognized in balancing the intracellular pools …

NME1 is a well-documented metastasis suppressor gene, with suppressor activity demonstrated across a wide spectrum of human cancers including melanoma and carcinomas of the breast, stomach and thyroid. A primary aim of the current study was to identify profiles of genes whose expression is regulated …

NME1 is located on chromosome 17q21 and encodes the NME1 protein, which contains 166 amino acids and functions to suppress metastasis. From: Pathology - Research and Practice, 2018