Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is encoded by the GRIN2B gene. [5] N -methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors.

NR2B基因是就大脑内“NMDA神经末梢”的一部分，科学家通过利用基因工程孕育出“聪明基因”，从而有助于记忆功能，从而为人类神秘而黑暗的大脑基因活动写下了新篇章。 脑科学是21世纪国际上最具挑战性和最活跃的前沿基础学科之一，了解脑的奥秘，揭开学习、记忆和高级认知功能的机制，对哺乳动物尤其是人类的生存极为重要。 于是研究小组通过检测大脑编码单元的活动状态来解读大脑在学习过程中记忆的形成。 因为人类大脑是一个由约140亿个神经元组成的繁复的神经网 …

NR2B is a double-edged sword for cognitive function, neuropathic pain, excitotoxicity, and schizophrenia. Heightened levels of NR2B in the PFC or forebrain can improve or recover cognitive performance and synaptic plasticity.

2014年4月18日 · 研究人员证实NR2B的第1116位丝氨酸被细胞周期依赖性蛋白激酶5（Cyclin-dependent kinase 5，Cdk5）磷酸化。依赖Cdk5的NR2B磷酸化是由神经元活动调节，并且控制受体细胞表面表达。

2003年1月1日 · NR2B is the most prominently tyrosine phosphorylated protein in the PSD fraction, based upon recognition by an anti-tyrosine antibody. NR2B-containing glutamate receptors may be regulated by tyrosine phosphorylation or may participate in signaling through tyrosine phosphorylation (Moon et al., 1994). In agreement with these findings ...

The N-methyl-D-aspartate (NMDA) receptor is an example of a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins by way of different subunits. NMDA receptors are composed of seven known subunits (NR1, NR2A-D, NR3A-B). The present review focuses on the NR2B subunit …

2003年1月13日 · Our recordings of experimentally defined activations of a single NR1/NR2B receptor allow us to unambiguously define intra-burst open and closed lifetimes for a fully liganded receptor.

2018年5月18日 · To address the role of PSD-95 in N-methyl-D-aspartate receptor subtype 2B (NR2B) -mediated chronic pain, we investigated the relationship between PSD-95 activation and NR2B function in the...

NR2B (AKA GluN2B/GRIN2B) is a subunit of NR2 which is part of NMDA receptors. NMDA receptors play a critical role in synaptic plasticity and learning and memory. Blocking NMDA receptors prevents the induction of long-term potentiation (LTP), …

2008年8月1日 · The NR2B subtype represents the most advanced in terms of drug development, with agents currently in clinical trials for chronic pain. Furthermore, memantine a new drug approved for use in Dementias is showing promise as a …