2024年12月25日 · NRG2 (Neuregulin 2) is a Protein Coding gene. Diseases associated with NRG2 include Tooth Disease and Charcot-Marie-Tooth Disease. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by ERBB2 KD Mutants.

Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

We show that NITRATE REGULATORY GENE2 (NRG2), which we identified using forward genetics, mediates nitrate signaling in Arabidopsis thaliana. A mutation in NRG2 disrupted the induction of nitrate-responsive genes after nitrate treatment …

Gene ID: 9542, updated on 8-Feb-2025. This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of …

2003年3月10日 · The neuregulins (NRGs) are cell-cell signaling proteins that are ligands for receptor tyrosine kinases of the ErbB family. The neuregulin family of genes has four members: NRG1, NRG2, NRG3, and NRG4. Relatively little is known about the biological functions of the NRG2, 3, and 4 proteins, and they are considered in this review only briefly.

Results: We found that NRG2 was differentially expressed in different grades of human glioma/glioblastoma tissues. The data from wound healing assays demonstrated that NRG2 can differentially promote the migration of SHG44 human glioma, and U251 and U-87 MG human glioblastoma cells at different time points.

Neuregulin-2/NRG2 蛋白作为 ERBB3 和 ERBB4 酪氨酸激酶受体的直接配体，启动配体刺激的酪氨酸磷酸化和这些受体的激活。 与此同时，NRG2 同时招募 ERBB1 和 ERBB2 辅助受体，可能促进与 EGF 受体的异二聚化。

In this study, we investigated the functions of AtNRG2 family members of Arabidopsis thaliana and maize in nitrate signalling and metabolism. Our results showed that both AtNRG2.10 and AtNRG2.15 regulated nitrate signalling and metabolism. Overexpression of AtNRG2.11 (AtNRG2) could promote plant growth and improve nitrogen use efficiency (NUE).

这个基因编码神经调节素家族的生长和分化因子的新成员。 通过与ERBB受体家族相互作用，该蛋白质诱导上皮、神经元、胶质细胞和其他类型细胞的生长和分化。 该基因由12个外显子组成，基因组结构与神经调节素1相似，神经调节素1是神经调节素家族配体的另一个成员。 这些基因的产品通过在组织中的不同部位发挥作用并在细胞中引发不同的生物反应，从而调节不同的生物过程。 这个基因位于脱髓鞘的Charcot-Marie-Tooth疾病位点的附近，但不是这种疾病的责任人。 已经描 …

2021年1月25日 · NRG2基因融合是一个全新的驱动基因异常，而且很有希望进行靶向治疗，但开展相关临床研究需要招募足够的患者，因此如果您是 NRG2基因融合的肿瘤患者，请联系我们，加入我们的研究小组，我们将留意并及时报道NRG2基因融合的相关内容， 最重要的是我们将积极寻求研究合作，为您带来接受新药治疗的机会。 NRG2基因融合虽然是罕见的驱动基因异常，但在特定人群中，其比例会有明显上升，但是目前 大部分患者无法接触到WTS服务，因此也很难检 …