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2024年12月25日 · NFIX (Nuclear Factor I X) is a Protein Coding gene. Diseases associated with NFIX include Malan Syndrome and Marshall-Smith Syndrome. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene expression (Transcription).

In embryonic cells, Nfix has been shown to regulate intermediate progenitor cell (IPC) generation by promoting the transcription of the protein inscuteable (INSC). INSC regulates spindle orientation to facilitate the division of radial glia cells into IPC's.

该基因编码的蛋白质是一种转录因子，可结合病毒和细胞启动子中的回文序列 5'-TTGGCNNNNNGCCAA-3。 编码的蛋白质还可以在体外刺激腺病毒复制。 已发现该基因的三个转录变体编码不同的亚型。 [RefSeq 提供，2012 年 8 月] The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro.

2025年2月25日 · NFIX is downregulated in breast cancer compared to normal breast tissue, which impacts prognosis. In vitro and in vivo Experiments have shown that the overexpression of NIFX leads to a delay in the G2/M phase, which inhibits breast cancer cell proliferation.

CircNFIX stimulates the proliferation, invasion, and stemness properties of ovarian cancer cells by enhancing SH3RF3 mRNA stability via binding LIN28B. A Novel Tumor-Promoting Role for Nuclear Factor IX in Glioblastoma Is Mediated through Transcriptional Activation of GINS1.

2025年2月26日 · 为探究乳腺癌分子发病机制，天津医科大学研究人员研究 NFIX 在乳腺癌中的作用，发现其抑制癌细胞增殖，为治疗提供新方向。 乳腺癌，这个全球范围内严重威胁女性健康的 “杀手”，一直以来都是医学领域研究的重点对象。 尽管当前手术、化疗、放疗、靶向治疗以及内分泌治疗等多种手段在一定程度上改善了乳腺癌患者的预后，但对于许多晚期患者而言，病情依旧不容乐观。 究其原因，人类对乳腺癌的分子发病机制尚未完全明晰，这就像在黑暗中摸索，难 …

2025年2月8日 · Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival. NFIX is robustly induced when neural stem cells enter quiescence; During vertebrate evolution, the transcription factor Nfix lost some specific functions, probably as a consequence of the different environment in which teleosts and mammals develop.

2024年9月28日 · NFIX基因过表达可上调与软骨细胞增殖和细胞外基质（extracellular matrix,EC）合成相关基因，并显著下调与软骨细胞分化和EC降 解相关基因，从而促进软骨细胞增殖和EC合成，反之NFIX基因表达

2016年3月8日 · Nfix belongs to a family of four highly conserved proteins that act as transcriptional activators and/or repressors of cellular and viral genes. We previously showed a pivotal role for Nfix in regulating the transcriptional switch from embryonic to fetal myogenesis. Here, we show that Nfix directly …