2020年3月16日 · NFKF blocked the production of IL-1beta and IL-6 from leukocytes. In silico NFKF binds with high scores to cannabinoid type 2 receptor. Previous studies suggested the pharmacological potential of rat hemopressin (PVNFKFLSH) and its shorter synthetic peptide NFKF, to protect from pilocarpine-induced seizures in mice.

2020年3月16日 · Previous studies suggested the pharmacological potential of rat hemopressin (PVNFKFLSH) and its shorter synthetic peptide NFKF, to protect from pilocarpine-induced seizures in mice. Orally administered NFKF was shown to be hundred times more potent than cannabidiol in delaying the first seizure indu …

2021年2月1日 · The short hemopressin-related fragment NFKF delay the first seizure induced by pilocarpine and prevent neurodegeneration in an experimental model of autoimmune encephalomyelitis. Hemopressin self-assembled nanofibrils have potential pharmaceutical applications for target drug-delivery systems.

2020年3月16日 · The shortest active hemopressin fragment, NFKF, delays the first seizure induced by pilocarpine, and prevents neurodegeneration in an experimental model of autoimmune encephalomyelitis. These functions of hemopressins could be due to engagement of both cannabinoid and non-cannabinoid receptor systems.

2020年1月28日 · Semantic Scholar extracted view of "NFKF is a synthetic fragment derived from rat hemopressin that protects mice from neurodegeneration" by A. Heimann et al.

加压素（大鼠中为PVNFK F LSH，人类和小鼠中为 PVNFK L LSH）是一种源自血红蛋白 α 链的片段，是第一个被描述为具有 1 型大麻素受体活性的肽。 虽然血加压素被证明具有反向激动/拮抗活性，但扩展形式的血加压素（即 RVD-血加压素，也称为 pepcan-12）表现出 1 型和 2 型大麻素受体激动/变构活性，最近的研究表明它们可以激活细胞内线粒体大麻素受体。 因此，加压素和加压素相关肽可能具有位置特异性和偏向性药理作用，这将增加微调和拓宽大麻素受体信号转导的 …

2020年1月28日 · Previous studies suggested the pharmacological potential of rat hemopressin (PVNFKFLSH) and its shorter synthetic peptide NFKF, to protect from pilocarpine-induced seizures in mice. Orally...

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2021年2月1日 · The shortest active hemopressin fragment, NFKF, delays the first seizure induced by pilocarpine, and prevents neurodegeneration in an experimental model of autoimmune encephalomyelitis. These functions of hemopressins could be due to engagement of both cannabinoid and non-cannabinoid receptor systems.

2021年1月5日 · The Hp central portion peptide NFKF acting through CB1R/CB2R was shown to significantly reduce the production of IL-1β and IL-6 by spleen leukocytes obtained from mice with experimental autoimmune encephalomyelitis, either unstimulated or when stimulated with anti-CD3 and myelin oligodendrocyte glycoprotein peptide 35–55 (Heimann et al., 2020).