This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.

OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. The original Guideline 423 was adopted in March 1996 as the second alternative to the conventional acute toxicity test, described in …

2023年9月13日 · OECD guidelines 420, 423 and 425 provide information on the hazardous properties and allow the substance to be ranked and classified according to the Globally Harmonised System (GHS) for the...

Learn more about our commitment to replacing, reusing and refining nonclinical research models. A stepwise procedure with the use of a minimal number of animals per step is used to obtain sufficient information on the acute toxicity of the chemical to enable its classification.

The currently used OECD TGs are: OECD TG 420 (Fixed Dose Procedure), OECD TG 423 (Acute Toxic Class Method), OECD TG 425 (Up-and-down procedure).

2002年2月8日 · OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute ... - OECD - Google Books. This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class...

Organisation for Economic Co-operation and Development. This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method. OECD Guidelines for the Testing of Chemicals, Section 4, 2074-5788. Stanford Libraries' official online search tool for books, media, journals, databases, government documents and more.

2024年1月1日 · Currently there are three test guidelines (TG) for acute oral toxicity studies of substances or mixtures from the Organisation for Economic Co-operation and Development (OECD). TG 423 and TG 425 use lethality as an endpoint, while TG 420 replaces death with ‘evident toxicity’, defined as clear signs that exposure to a higher dose would ...

OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. The original Guideline 423 was adopted in March 1996 as the second alternative to the conventional acute toxicity test, described in …

OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. The original Guideline 423 was adopted in March 1996 as the second alternative to the conventional acute toxicity test, described in …