2018年1月1日 · OCT4 is a member of the class 5 POU (Pit-Oct-Unc) family of homeodomain transcription factors. It is so named because of its specific binding to the canonical octamer motif (with consensus sequence ATGCA/TAAT) at target gene promoter or enhancer regions.

This review mainly proposes the specific role of OCT4 in CSCs from the epigenetic modification of OCT4 and complexes, non-coding RNA and signaling pathways related to OCT4, which may provide multiple targets for the treatment of CSCs to achieve the purpose of extending patient life.

Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs) or their differentiation into trophoblast. Oct4 of ...

2022年5月27日 · Time-resolved multiomics analysis during Oct4 depletion and recovery reveals concentration-dependent activities of Oct4 in controlling enhancer transcription and chromatin accessibility in mouse embryonic stem cells.

In this review, we summarize the structure and function of Oct4 and address issues related to Oct4 function in maintaining totipotency or pluripotency of embryonic stem cells.

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Oct4 is one of the most important transcription factors required to maintain an undifferentiated state (self-renewal) and pluripotency of human and mouse embryonic stem (ES) cells as well as early embryonic cells. In addition, Oct4 is the only known ...

OCT4 was discovered more than two decades ago as a transcription factor specific to early embryonic development. Early studies with OCT4 were descriptive and looked at determining the functional roles of OCT4 in the embryo as well as in pluripotent cell lines derived from embryos.

2013年6月24日 · The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4’s major early activity in the blastocyst is to support primitive endoderm differentiation.

5 天之前 · Oct4 has long been considered the most important among the four Yamanaka reprogramming factors. However, as scientists have continued to explore the ins and outs of reprogramming, Oct4’s role has proven to be more nuanced. Rather than serving as a single, master conductor, scientists are identifying various partnerships between Oct4 forms and ...