p16 mosaic (patchy and weak nuclear / cytoplasmic expression) To be considered positive, p16 must have strong, diffuse, block-like nuclear and cytoplasmic positivity throughout the area of interest Caveat: high grade (FIGO 3) tumors can show aberrant expression (Gynecol Oncol 2004;94:449, Am J Surg Pathol 2009;33:1504)

2023年5月10日 · p16: diffuse and strong nuclear and cytoplasmic reactivity (block type staining); improper use / interpretation may lead to overdiagnosis of HSIL Surgical excision is the treatment of choice, except during pregnancy or CIN II in females < 25 years old

P glycoprotein p16 p21 p40 p53 p57 p62 (pending) p63 p120 catenin P504S Pan-TRK PAP PAS PAX2 PAX5 PAX8 PCNA PD-1 PDL1 22C3 PDL1 SP142 PDL1 SP263 (pending) PECAM1 perforin (pending) PGP9.5 (pending) PHLDA1 (pending) phosphohistone H3 Pit1 PLAG1 PLAP PMS2 podoplanin PRAME prealbumin (pending) progesterone receptor (PR) …

2020年1月30日 · The carcinoma shown in the image above, which involves the surface of an endometrial polyp, shows strong and diffuse positivity for p53 and p16. Which of the follow is true regarding the above carcinoma? Likely arose in a patient less than 30 years of age Considered an estrogen dependent endometrial carcinoma

principaux : p16 surexprimé / p53 normal, p16 négatif / p53 anormal et p16 négatif/ p53 normal. y Les carcinomes indépendants du HPV (p16 négatif), p53 anormal sont associés à des taux de survie sans aggravation et de survie globale plus mauvais que pour les carcinomes dépendants du HPV et carcinomes p16 négatif /p53 normal.

2018年2月4日 · Homozygous deletion of CDKN2A (p16) by FISH All mesothelioma Epithelioid mesothelioma Sarcomatoid mesothelioma 58 - 62 48 - 78 67 100; Loss of BAP expression or homozygous deletion of CDKN2A All mesothelioma Epithelioid mesothelioma Sarcomatoid mesothelioma 58 - 92 92 67 - 100 100

Tumor cells demonstrate slightly elevated but patchy p53 wild type staining. p16 also demonstrates patchy staining. The findings are consistent with involvement by serous carcinoma of Müllerian origin and the overall morphologic features, low mitotic activity and wild type p53 and p16 staining support the diagnosis of low grade serous carcinoma.

2024年4月2日 · D. p16. IHC for p16 shows highest specificity and sensitivity for HPV association. Answers A, B, C and E are incorrect because they are not relevant for verification of HPV association. Comment Here Reference: HPV associated squamous cell carcinoma-vulva

2022年6月13日 · Ancillary studies: The malignant cells are diffusely positive for cytokeratin 5/6, p40 and p16 and are negative for cytokeratin 7, supporting the diagnosis. Board review style question #1 A 55 year old male construction worker with a 20 pack year smoking history and no prior diagnosis of malignancy, presents with a lung mass, which is biopsied.

2024年5月9日 · p16 and HPV negative Condyloma latum (Cheng: Urologic Surgical Pathology, 4th Edition, 2019, Rom J Morphol Embryol 2021;62:369): Cutaneous lesion of secondary syphilis caused by Treponema pallidum; Appear as wet, sometimes weepy plaques Dark field microscopy can be used to visualize spirochetes