Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. [5] It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins.

2024年12月24日 · cDNA, FLJ92816, Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1)(CDKN1B), mRNA (Q6I9V6_HUMAN) Cyclin-dependent kinase inhibitor 1B (Q708J1_HUMAN) Graphical View of Domain Structure for InterPro Entry

Test out the new Winchester Speedpark SX track! Join us for P27 Under the Lights. More details to come…

The cyclin-dependent kinase (Cdk) inhibitor p27 regulates cell proliferation, cell motility and apoptosis, and is inactivated through various means in many types of human cancer.

2020年9月2日 · p27 plays cell-cycle–independent actions to regulate cell motility . Early work showed transduction of p27–TAT fusion protein into HepG2 cells increased cytoplasmic p27 and promoted cell migration .

However, loss of p27 results in a more pronounced phenotype, and strong evidence suggests that p27 does indeed lead to an increased incidence of certain cancers. Below we discuss critical studies that implicate p21 and p27 as important mediators of carcinogenesis.

P27 may refer to: CDKN1B, cyclin-dependent kinase inhibitor 1B; ČZ vz. 27, a pistol; IFI27, interferon alpha-inducible protein 27; Papyrus 27, a biblical manuscript; Phosphorus-27, an isotope of phosphorus; Pixley Airport, in Tulare County, California, United States; Projekt-27, an intelligence-gathering unit of the Swiss Armed Forces

The p27 protein is a global cyclin-dependent kinase inhibitor (encoded in chromosome 12p12–12p13.1) that can bind all essential cdk types to potentially intervene the cellular cycle in several phases, the earliest of which is the restriction point between early (growth factor dependent) G1 and later growth factor independent phases.

Mutations, abnormal expression and mislocalization of p27 have been found in many diseases suggesting the important role of p27 in the pathogenesis of diseases. Human p27 gene ( CDKN1B ) was cloned in 1994 7 and mapped to chromosome 12p13.

2020年9月1日 · Recent data indicate p27 regulates transcription and acts as a transcriptional coregulator of cJun. C-terminal p27 phosphorylation increases p27-cJun recruitment to and action on target genes to drive oncogenic pathways and repress differentiation programs.