PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. [5] In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1.

2024年12月25日 · PDX1 (Pancreatic And Duodenal Homeobox 1) is a Protein Coding gene. Diseases associated with PDX1 include Maturity-Onset Diabetes Of The Young, Type 4 and Pancreatic Agenesis 1. Among its related pathways are Regulation of beta-cell development and Hepatic ABC Transporters.

摘 要:Pdx1 (pancreatic and duodenal homeobox 1) 是一种同源框转录因子,在胰腺发育及β细胞功能维持中起重要调控作用。 研究发现,Pdx1 基因纯合缺失会导致胰腺发育不全;在β细胞成熟与分化过程中,Pdx1 通过协同其他因子或以顺式调控的方式参与调节;此外,Pdx1可以直接与胰岛素启动子结合,调节胰岛素合成与分泌。 近来针对Pdx1 的研究表明,它在β细胞重塑、基因编辑及药物开发等方面具有重要作用。 现就Pdx1在胰腺发育中的作用机制及其在糖尿病治疗中的进展进行综述。

Pdx1 is a transcription factor required for the formation of endocrine pancreas that is inhibited during Coxsackievirus B4 infection of human pancreas ductal cells; recessive PDX1 mutations are a rare but important cause of isolated permanent neonatal diabetes in patients without pancreatic hypoplasia/agenesis

Pdx1-Cre小鼠是一种在胰岛细胞同源框转录因子1（Pancreatic and Duodenal Homeobox 1, Pdx1）基因座插入Cre重组酶的转基因小鼠模型。Pdx1是胰腺发育和β细胞功能的重要调控因子，主要在胰腺和十二指肠的发育过程中表达。Pdx1-Cre小鼠广泛用于研究胰腺发育、β细胞功能及相关疾病（如糖尿病）的机制。

2022年12月14日 · PDX1 is a master regulator in pancreas organogenesis, the maturation and identity preservation of β-cells, and of their role in normal insulin function.

2022年12月15日 · pdx1 是胰腺器官发生、β 细胞的成熟和特性保存以及它们在正常胰岛素功能中的作用的主要调节因子。 PDX1 基因突变与许多胰腺功能障碍相关，包括胰腺发育不全（纯合突变）和 MODY4（杂合突变），而在其他类型的糖尿病中，PDX1 表达减少。

pdx1通过与胰岛素启动子区的特定dna序列结合 来反式激活胰岛素,pdx1活性的降低可能是导致 t2dm中胰岛β细胞失调的关键。成人正常的胰岛 功能需要pdx1,pdx1减少会影响葡萄糖传递和胰 岛素分泌。cpg岛是位于编码序列附近的富含cg

It has been shown that PDX-1 is required for maintaining pancreatic islet functions by activating gene expression and has a dual role in pancreatic development. It initially contributes to pancreatic formation during embryogenesis and subsequently regulates the pancreatic islet cell physiology in mature islet cells.

胰腺十二指肠同源盒1 (PDX-1),是目前较公认的胰腺干细胞的特异性标志,是胰腺分化发育关键的转录因子.PDX-1基因的活化可促进胰岛素、生长抑素、葡萄糖激酶等胰腺β细胞重要基因的表达,是胰腺干细胞诱导分化为胰岛素分泌细胞的必要条件之一.肝细胞核因子3β、肝细胞核因子-6、胰升糖素样肽-1等通过多种细胞信号途径共同调节PDX-1基因的表达.了解PDX-1的基因表达及调节的作用机制有助于促进干细胞诱导分化为胰岛素分泌细胞的研究进展。 引用本文: 朱岚, 陆颖理. PDX-1 …