2017年8月10日 · Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer.

Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K pathway-targeted therapies have been tested in oncology trials, ...

The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially regulated and multifunctional, and together, act at nearly all membranes ...

Phosphoinositide 3-kinase (PI3-K) is a dual-specificity kinase with lipid and protein kinase activity. One of its targets is the protein kinase B (PKB or Akt) [89]. The PI3-K/PKB pathway has been shown to deliver an anti-apoptotic signal [90–92], which is negatively regulated by the lipid and protein phosphatase PTEN, a tumour suppressor gene [93].

Phosphatidylinositol 3-kinase (PI3K) is lipid kinases that regulate diverse cellular processes including proliferation, adhesion, survival, and motility. Dysregulated PI3K pathway signaling occurs in one-third of human tumors.

2019年5月20日 · PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided into...

As a central hub for cellular signaling, PI3K is an important regulator of cellular growth and function. This Review focuses on its basic signaling mechanisms as well as its role in metabolism and immune function in the context of cancer.

2025年3月4日 · The deregulated activation of the phosphoinositide 3-kinase (PI3K) pathway is a hallmark of aggressive tumors with metabolic plasticity, eliciting their adaptation to the microenvironment and ...

2025年2月14日 · Pan-PI3K inhibitors. The pan-PI3K inhibitors such as Wortmannin and LY294002, were non-selective, targeting multiple PI3K isoforms and subsequently limiting their clinical utility due to significant off-target effects and poor pharmacokinetic profiles [62, 63].PX-866 is a semi-synthetic derivative of wortmannin, which functions as an orally available and …

2025年3月10日 · Phosphoinositide 3-kinases (PI3Ks), members of the lipid kinase family, play a significant role in modulating immune cell functions, including activation, proliferation, and differentiation. Recent studies have identified the PI3K signaling pathway as a key regulator in tumor biology and the immune microenvironment. This pathway enhances the activity of …