PRC2 - Wikipedia
PRC2 (polycomb repressive complex 2) is one of the two classes of polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1 (Polycomb Repressive Complex …
The Polycomb Complex PRC2 and its Mark in Life - PMC
We focus here on PRC2, which is involved in various processes, including differentiation, cell identity and proliferation, and stem cell plasticity. Recent studies of PRC2 have expanded our …
Role of the Polycomb Repressive Complex 2 (PRC2) in …
PRC2 is involved in establishing and maintaining gene expression patterns and, in turn, cell fates. Activating and inactivating mutations in genes encoding PRC2 contribute to human cancers, …
PRC2, Chromatin Regulation, and Human Disease: Insights From
2022年6月21日 · Polycomb repressive complex 2 (PRC2) is a multisubunit histone-modifying enzyme complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated …
The Polycomb complex PRC2 and its mark in life - Nature
2011年1月19日 · In mammals, two main Polycomb group complexes exist — Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the …
PRC2, Chromatin Regulation, and Human Disease: Insights From …
Polycomb repressive complex 2 (PRC2) is a multisubunit histone-modifying enzyme complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 (H3K27me3) is …
Structure of the PRC2 complex and application to drug discovery
2017年4月17日 · Overexpression and mutations of PRC2 are found in a wide variety of cancers, making the catalytic activity of PRC2 an important target of cancer therapy.
PRC2-RNA interactions: Viewpoint from YongWoo Lee and …
2024年10月3日 · Here, we expound on the view that Xist RNA directly controls Polycomb repressive complex 2 (PRC2) recruitment, off-loading to chromatin, catalytic activity, and …
Novel insights into the dynamic function of PRC2 in innate immunity
2024年11月26日 · PRC2 catalyzes methylation of histone H3 at lysine 27 (H3K27me3) and is known for maintaining eukaryote cell identity. Recent discoveries show that modulation of …
Engaging chromatin: PRC2 structure meets function
2019年11月11日 · Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex involved in the regulation of gene expression in metazoans.