2024年12月25日 · PIGK (Phosphatidylinositol Glycan Anchor Biosynthesis Class K) is a Protein Coding gene. Diseases associated with PIGK include Neurodevelopmental Disorder With Or …

GPI转酰胺酶复合物是GPI锚定蛋白生物合成第二步的关键催化酶，由五个亚基组成，包括 PIGK、PIGU、PIGT、PIGS和GPAA1。 糖基磷脂酰肌醇（GPI）是一类由甘露糖、葡萄糖胺、磷酸 …

The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme GPI transamidase and is thought …

GPI 锚是一种在许多血细胞上发现的糖脂，用于将蛋白质锚定到细胞表面。 该蛋白质是多亚基酶 GPI 转酰胺酶的成员，被认为是其酶促成分。 GPI 转酰胺酶通过催化完全组装的 GPI 单位向蛋 …

2024年11月9日 · To examine the function of PIGK in cerebellar pathogenesis, we first investigated the expression of PIGK in the mouse brain and found that it was highly expressed …

PIGK gene, encoding a key component of glycosylphosphatidylinositol (GPI) transamidase, was recently reported to be associated with inherited GPI deficiency disorders (IGDs). However, …

2025年2月8日 · Microsatellite polymorphism located immediately upstream of the phosphatidylinositol glycan, class K gene (PIGK) affects its expression, which correlates with …

2025年2月8日 · Our results demonstrate, for the first time, a link between the SNP 1048575 and low PIGK expression in CRC/HCC patients and also suggest a possible association between …

2024年11月9日 · Biallelic mutations in PIGK cause GPI biosynthesis defect 22 (GPIBD22), characterized with developmental delay, hypotonia, and cerebellar atrophy. The understanding …

2020年4月4日 · PIGK encodes a component of the GPI transamidase complex, which attaches the GPI anchor to proteins. Clinical features found in most individuals include global …