Piwi-interacting RNA (piRNA) is the largest class of small non-coding RNA molecules expressed in animal cells. [1] [2] [3] piRNAs form RNA-protein complexes through interactions with piwi-subfamily Argonaute proteins.

Pirna (German: ⓘ; Upper Sorbian: Pěrno, pronounced [ˈpʲɪʁnɔ]) is a town in Saxony, Germany and capital of the administrative district Sächsische Schweiz-Osterzgebirge. The town's population is over 37,000. Pirna is located near Dresden and is an important district town as well as a Große Kreisstadt.

PIWI-piRNA silencing complexes (piRISC) degrade transposon transcripts in the cytoplasm and establish epigenetic restriction in the nucleus. PiRNAs are largely confined to germ cells but the initial epigenetic restriction they impose is maintained in adult somatic cells …

2018年11月16日 · Here, we discuss how a common piRNA pathway allows animals to recognize diverse targets, ranging from selfish genetic elements to genes essential for gametogenesis.

PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24-31 nucleotides in length. They associate with PIWI proteins, which constitute a germline-specific subclade of the Argonaute family, to form effector complexes known as piRNA-induced silencing complexes, which repress transposons vi …

2024年9月26日 · PIWI-interacting RNAs (piRNA) suppress selfish genetic elements and are essential for germ cell biology in animals. They also play critical roles in regeneration in planaria, regulate gene expressi...

2022年9月14日 · In this Review, we discuss the most recent advances in our understanding of piRNA biogenesis, the molecular mechanisms of piRNA function and the emerging roles of piRNAs in germ line...

Unregulated piRNA expression has been reported in human cancers such as colorectal cancer, lung cancer, breast cancer, bladder cancer, and gastric cancer . Overall, 6260 piRNA transcriptome of human were studied from normal and tumor tissues .

This review illustrates piRNA biogenesis, mechanisms behind piRNA-mediated gene regulation, and changes of piRNAs in different diseases, especially in cancers. Keywords: piRNA, Piwi, disease, cancer Graphical Abstract

2020年9月4日 · Mounting studies have revealed that the dysregulation of piRNAs may cause epigenetic changes and contribute to diverse diseases. This review illustrates piRNA biogenesis, mechanisms behind piRNA-mediated gene regulation, and changes of piRNAs in different diseases, especially in cancers.