2024年12月25日 · PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases associated with PLAU include Quebec Platelet Disorder and Alzheimer Disease, Familial, 1. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Innate Immune System.

Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein was discovered, but not named, by McFarlane and Pilling in 1947. [5] .

2025年1月4日 · Title: PLAU contributes to the development of cholangiocarcinoma via activating NF-κB signaling pathway. Involvement of matrix metalloproteinase 1 and urokinase-type plasminogen activator in the PKCalpha-p38 MAPK pathway-mediated progression of …

PLAU is a promising new candidate gene for late-onset Alzheimer's disease, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection. u-PA down-regulation by RNAi technology decreases the invasive capability of hepatocellular carcinoma cells

2025年1月4日 · Clinical resource with information about PLAU, Alzheimer disease type 1, Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease., Quebec platelet disorder, and available tests.

2021年5月20日 · Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. However, the biological functions and potential mechanisms of PLAU in head and neck squamous cell …

Elevated PLAU correlates with increased aggressive phenotypes, stromal score, and immune suppression in PDAC. PLAU upregulation is also closely associated with the basal subtype type of PDAC; patients with this subtype are at high risk of mortality from the disease and may benefit from therapeutic targeting of PLAU.

PLAU is a protease that converts plasminogen to plasmin. It appears to affect murine ageing: its overexpression in the brain diminishes food consumption and extends longevity probably through a mechanism similar to caloric restriction [13].

2017年3月16日 · Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and platelets but not in plasma or urine. The cause is tandem duplication of a 78 kb region of chromosome 10 containing PLAU (the uPA gene) and C10orf55, a gen …

Plau am See (German: [plaʊ̯ am ˈzeː] ⓘ) is a town in the Ludwigslust-Parchim district, in Mecklenburg-Western Pomerania, in north-eastern Germany. It is situated 28 kilometres (17 mi) east of Parchim, and 29 kilometres (18 mi) west of Waren.