2023年12月7日 · Prenylation is the covalent attachment of an isoprenyl group to a protein, and is one of the most common post-translational modifications. In mammals, up to 2% of cellular proteins undergo prenylation. These modifications mediate both protein-membrane and protein–protein interactions.

Prenylation is the first reaction in a three‐step maturation process that involves initial attachment of the prenyl group to a specific cysteine residue present near the C‐terminus of a protein via the formation of a thioether bond. This reaction is catalyzed by a class of enzymes called protein prenyl transferases that use either farnesyl ...

2016年3月8日 · These characteristic features of TleC and MpnD make the enzymes excellent targets for the manipulation of the prenylation reactions. The structure-based engineering of TleC and MpnD...

Prenylation (also known as isoprenylation or lipidation) is the addition of hydrophobic molecules to a protein or a biomolecule. It is usually assumed that prenyl groups (3-methylbut-2-en-1-yl) facilitate attachment to cell membranes, similar to lipid anchors like the GPI anchor, though direct evidence of this has not been observed.

Tandem mass spectrometry, when combined with micro-HPLC, provides a method for characterizing the entire C-terminal structure of the protein of interest (prenylation, proteolysis, and methylation). Because of mass speciation, this method is useful for analyzing complex mixtures such as tryptic digests of native proteins.

Inhibitors of prenyltransferase have resulted in substantial therapeutic benefits in various diseases, such as cancer, neurological disorders, and viral and parasitic infections. In this review, we overview the structure of FTase, GGTase-I, GGTase-II, and GGTase-III and summarize the current status of research on their inhibitors.

Protein prenylation is a ubiquitous covalent post-translational modification found in all eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. It is essential for the proper cellular activity of numerous ...

蛋白质的异戊二烯化（prenylation）是脂化修饰的一种，指在受体蛋白质上添加聚异戊二烯（萜类）修饰基团。 萜类基团通过硫醚键连接在蛋白质羧基末端的半胱氨酸侧链巯基上。

2022年1月10日 · Prenylation is a universal covalent post-translational modification found in all eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. Prenyl group is important for protein-protein binding through specialized prenyl-binding domains.

Prenylation is a posttranslational modification in which an isoprenoid moiety is transferred to a cysteine near the C-terminus of a substrate protein. This modification helps to localize proteins to cellular membranes and facilitate protein-protein interactions.