Proline is a non-essential amino acid with key roles in protein structure/function and maintenance of cellular redox homeostasis. It is available from dietary sources, generated de novo within cells, and released from protein structures; a noteworthy source being collagen.

Arginine and proline metabolism is one of the central pathways for the biosynthesis of the amino acids arginine and proline from glutamate. The pathways linking arginine, glutamate, and proline are bidirectional. Thus, the net utilization or production of these amino acids is highly dependent on cell type and developmental stage.

2020年10月14日 · The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread.

Proline is a non-essential amino acid with key roles in protein structure/function and maintenance of cellular redox homeostasis. It is available from dietary sources, generated de novo within cells, and released from protein structures; a noteworthy source being collagen.

Proline and hydroxyproline are unique AA for maintaining cell structure and function. There are remarkable species differences in proline metabolism and requirements among vertebrate animals during the life cycle. However, emerging evidence consistently points to proline as an important regulator of cell metabolism and physiology.

Metabolism of proline generates electrons to produce ROS and initiates a variety of downstream effects, including blockade of the cell cycle, autophagy, and apoptosis. The electrons can also enter the electron transport chain to produce adenosine triphosphate for …

2025年2月25日 · In recent decades, arsenic (As) toxicity has emerged as a significant challenge in many countries. It not only reduces the growth and performance of plants, but also poses a threat to human health. The synthesis of compatible solutes, particularly proline, is a mechanism plants utilize to cope with stress. Investigating the metabolic pathways of proline would deepen our understanding for ...

2019年2月1日 · Once understood as a central mechanism in cancer metabolism, proline metabolism may be a good target for adjunctive cancer therapy. The proline metabolic axis can serve as a scaffold on which a variety of regulatory mechanisms are integrated.

2020年5月15日 · Here we discuss the impact of proline metabolism in cancer development and progression, with particular emphasis on the enzymes involved in proline synthesis and catabolism, which are linked to pathways of energy, redox, and anaplerosis.

2023年12月1日 · Proline metabolism regulates the crosstalk between cancer cells and the TME, influencing tumor progression and response to therapy. Intuitively, proline metabolism contributes toward the synthesis of proline-rich collagen, but it also shapes the immune TME and the efficacy of immune therapy in cancer patients ( Figure 1 ).