2024年12月25日 · PUM1 (Pumilio RNA Binding Family Member 1) is a Protein Coding gene. Diseases associated with PUM1 include Spinocerebellar Ataxia 47 and Neurodevelopmental Disorder With Motor Abnormalities, Seizures, And Facial Dysmorphism. Among its related pathways are Vesicle-mediated transport and trans-Golgi Network Vesicle Budding.

Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene. [4] This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans.

2020年7月27日 · pum1通过降低多能性相关基因的表达从而促进胚胎干细胞的分化。 与其不同的是，PUM2则旨在维持胚胎干细胞的自我更新，抑制干细胞过早分化。 这一发现第一次揭示了Pumilio同源基因在胚胎干细胞中的不同功能，对同源蛋白进行了更为精细的分类，有利于将来 ...

2022年3月25日 · Here, we report that Pum1 and Pum2 display increased expression in human colorectal cancer (CRC). Intestine-specific knockout of Pum1 and Pum2 in mice significantly inhibits the progression of...

编码的蛋白质包含一个序列特异性 RNA 结合结构域，该结构域由八个重复序列和 N 和 C 末端侧翼区域组成，并通过结合其 3' 非翻译区作为特定 mRNA 的翻译调节剂。 编码蛋白在无脊椎动物和低等脊椎动物中的进化保守功能表明，人类蛋白可能参与胚胎发生、细胞发育和分化的翻译调节。 已经描述了编码不同亚型的选择性剪接转录物变体。 [RefSeq 提供，2008 年 7 月]

2024年12月29日 · 本文将详细介绍PUM1基因的意义和作用，包括其位置、功能、同源域、编码蛋白及其在生物学中的重要性。 什么是PUM1基因？ PUM1基因，全名为pumilio RNA binding family member 1 ，位于人类染色体1p35.2 。

Mechanistically, PUM1 binds directly to DEPTOR mRNA pumilio response element to maintain the stability of the transcript and prevent DEPTOR degradation through post-transcriptional pathway. PUM1-mediated DEPTOR upregulation inhibits mTORC1 and alleviates the inhibitory feedback signal transmitted from mTORC1 to PI3K under normal conditions ...

2022年1月16日 · Gene therapy using a lentiviral vector encoding mouse PUM1 showed promise in preserving articular cartilage integrity in OA mouse models. In conclusion, PUM1 is a novel suppressor of MSC aging,...

2021年3月31日 · Pumilio-1 (PUM1) is an RNA binding protein whose regulatory role is by binding to the consensus 5'UGUANAUA3' sequence on the 3'UTR of the mRNA targets and post-transcriptionally repressing their expression. This study is the first of its kind to report the expression or function of PUM1 in colon cancer.

2020年11月19日 · Pumilio homologous protein 1 (PUM1) promotes cell growth, invasion, and metastasis and suppresses apoptosis in many different kinds of cancers, such as non-small-cell lung carcinoma (NSCLC), ovarian cancer and lymphocyte leukemia. However, the underlying mechanism and potential role of PUM1 in PAAD have not been investigated.