Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely related to focal adhesion kinase (FAK), which plays an important role in sensing cell contacts with extracellular matrix and other extracellular signals controlling adhesion and survival.

2024年4月1日 · PYK2 functions as a signaling hub in various cascades, and its involvement in positive and negative feedback loops enhances signaling robustness, modulates signaling dynamics, and contributes to BC growth, epithelial-to-mesenchymal transition (EMT), stemness, migration, invasion, and metastasis.

聚合黏附激酶 (Focal adhesion kinase, FAK)是一种非受体酪氨酸激酶，也是一种连接蛋白，主要调节黏附信号传导和细胞迁移，但FAK也可以促进细胞在应激反应中的生存。 FAK在癌症中普遍过表达，并被认为是高价值的药物靶点，目前有多种FAK抑制剂正在开发中。 有证据表明，在临床环境中，FAK靶向联合其他药物将是最有效的，从而逆转化疗或靶向治疗的失败，并增强基于免疫的实体肿瘤治疗的疗效。 简介：

2018年11月14日 · Proline-rich tyrosine kinase 2 (Pyk2) plays essential roles in tumorigenesis and tumor progression. Pyk2 serves as a non-receptor tyrosine kinase regulating tumor cell survival, proliferation, migration, invasion, metastasis, and chemo-resistance, and is associated with poor prognosis and shortened …

富含脯氨酸的酪氨酸激酶2（proline-rich tyrosine kinase 2，Pyk2）是黏着斑激酶（focal adhesion kinase，FAK）家族的一员，Pyk2可使多种含SH2结构域的底物蛋白发生磷酸化，从而参与包括离子通道激活、细胞黏附、骨架重组等多种信号转导通路的调节，使细胞迁移、存活 ...

摘要： 富含脯氨酸的酪氨酸激酶2（proline-rich tyrosine kinase 2，Pyk2）广泛存在于细胞和组织中，参与多种生理及病理过程，发挥其生物学效应。 Pyk2依赖N-末端、C-末端和中心激酶结构3个部分实现其对细胞外信号的迅速反应，通过膜联受体活化及自磷酸化等机制实现其自身的活化，激活下游信号分子，进而启动细胞信号转导通路，最终发生一系列细胞形态及功能变化。 就目前对Pyk2参与细胞信号转导通路的研究进行综述，以期深入而全面地了解Pyk2的作用，为相关疾 …

2022年8月9日 · Here, we investigated the mechanism by which the protein tyrosine kinase 2-beta (PYK2) functions as a sensor and effector of cellular calcium influx. We show that the linker between the PYK2...

Pyk2 is a Ca 2+ -activated non-receptor tyrosine kinase enriched in forebrain neurons and involved in synaptic regulation. Human genetic studies associated PTK2B, the gene coding Pyk2, with risk for Alzheimer's disease (AD).

The protein tyrosine kinase Pyk2 is encoded by PTK2B, a novel Alzheimer's disease (AD) susceptibility variant, with the PTK2B risk allele being associated with increased mRNA levels, suggestive of increased Pyk2 levels. However, the role of Pyk2, a member of the focal adhesion kinase (FAK) family, i …

Proline-rich tyrosine kinase 2 (Pyk2) is a nonreceptorprotein tyrosine kinase related to focal adhesion kinase (FAK). Pyk2 is activated by an array of stimuli, including G protein-coupled receptor agonists, hormones, growth factors, integrin-mediated cell adhesion, in-flammatory cytokines, and environmental stress, via a mechanism that involves ...