2024年5月7日 · We demonstrate that the deficiency of quinoid dihydropteridine reductase (QDPR), a critical enzyme regulating biopterin metabolism, causes metabolite dihydrobiopterin (BH2) accumulation and decreases the ratio of tetrahydrobiopterin (BH4) to BH2 in pancreatic ductal adenocarcinomas (PDACs).

Quinoid dihydropteridine reductase is one of two enzymes that help recycle tetrahydrobiopterin in the body. More than 30 mutations in the gene have been found to cause tetrahydrobiopterin deficiency. When this condition results from gene mutations, it is known as dihydropteridine reductase (DHPR) deficiency.

We demonstrate that the deficiency of quinoid dihydropteridine reductase (QDPR), a critical enzyme regulating biopterin metabolism, causes metabolite dihydrobiopterin (BH2) accumulation and de-creases the ratio of tetrahydrobiopterin (BH4) to BH2 in pancreatic ductal adenocarcinomas (PDACs).

Infants with tetrahydrobiopterin deficiency appear normal at birth, but medical problems ranging from mild to severe become apparent over time.

2022年3月31日 · Conclusions: The peak VO 2 /kg is independently associated with all-cause death in patients with PH-LHD. The peak VO 2 /kg can also be analyzed together with Cpc-PH/Ipc-PH to better indicate the prognosis of patients with PH-LHD.

2024年12月25日 · QDPR (Quinoid Dihydropteridine Reductase) is a Protein Coding gene. Diseases associated with QDPR include Hyperphenylalaninemia, Bh4-Deficient, C and Hyperphenylalaninemia, Bh4-Deficient, A. Among its related pathways are Tyrosine catabolism and L-phenylalanine degradation I (aerobic).

2024年4月11日 · Clinical resource with information about QDPR, Dihydropteridine reductase deficiency, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2024年9月19日 · Mutation of dihydropteridine reductase (QDPR) inhibited the regulation of TOR serine-threonine kinases (mTOR), suggesting that QDPR is a positive regulator of autophagy via suppressing mTOR signaling. Title: A278C mutation of dihydropteridine reductase decreases autophagy via mTOR signaling.

Quinoid dihydropteridine reductase is one of two enzymes that help recycle tetrahydrobiopterin in the body. More than 30 mutations in the QDPR gene have been found to cause tetrahydrobiopterin deficiency. When this condition results from QDPR gene mutations, it is known as dihydropteridine reductase (DHPR) deficiency.

Dihydropteridine reductase (EC 1.6.99.7) catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin and is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems (Lockyer et al., 1987).