2022年5月1日 · The retinal pigment epithelium 65 kDa protein (RPE65) is a critical component of the vertebrate visual system, playing a non-redundant role in the visual cycle metabolic …

RPE65 catalyzes the conversion of all-trans-retinyl ester to 11-cis-retinol through a proposed S N 1 O-alkyl bond cleavage. RPE65's combination of an O-alkyl ester cleavage, geometric …

视网膜色素上皮 (RPE)是由排列在视网膜最外层的一层规则的多边形细胞组成。 RPE的外侧连接布鲁赫膜和脉络膜，内侧连接光感受器细胞的外节。 外侧呈现出基底内折叠样，这增加了细胞 …

RPE65 is an isomerohydrolase expressed in retinal pigment epithelium. It is critical for the regeneration of the visual pigment necessary for both rod and cone-mediated vision. Mutations …

At the heart of this metabolic pathway is an enzyme known as retinal pigment epithelium 65 kDa protein (RPE65), which catalyzes an unusual, possibly biochemically unique, reaction …

2025年3月30日 · RPE65 (Retinoid Isomerohydrolase RPE65) is a Protein Coding gene. Diseases associated with RPE65 include Retinitis Pigmentosa 20 and Leber Congenital Amaurosis 2. …

2022年9月26日 · Voretigene neparvovec (VN) is a gene therapeutic agent for treatment of retinal dystrophies caused by bi-allelic RPE65 mutations. We illustrate, both the benefits and pitfalls …

为了使用 CRISPR-Cas9技术 来治疗先天性黑蒙症，研究人员首先使用了来自rd12小鼠的 胚胎成纤维细胞 (MEFs)来筛选针对Rpe65外显子3的单导RNA (sgRNA)序列，并最终确定了一个优化 …

The RPE65 gene provides instructions for making a protein that is essential for normal vision. The RPE65 protein is produced in a thin layer of cells at the back of the eye called the retinal …

The RPE65 protein is the source of isomerohydrolase activity (conversion of all-trans retinyl ester to 11-cis retinol) in the retinal pigment epithelium (summary by Moiseyev et al., 2005). The …