RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template.

2022年2月15日 · RdRp are proteins that are involved in the replication of RNA-based viruses. Inhibition of RdRps has been an integral approach for managing various viral infections such as dengue, influenza, HCV (Hepatitis), BVDV, etc. Inhibition of the coronavirus RdRp is currently rigorously explored for the treatment of Covid-19 related complications.

病毒RNA复制酶，也称RNA依赖的RNA聚合酶（RNA-dependent RNA polymerase, RdRp）负责RNA病毒基因组的复制和转录，在病毒在宿主细胞中的自我复制过程中扮演着非常重要的作用。

RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA viruses that is indispensable for replicating the genome as well as for carrying out transcription. The core structural features of RdRps are conserved, despite the divergence in their sequences.

2022年5月16日 · RNA复制酶 （RNA replicase）或名 RNA依赖性RNA聚合酶 （RNA-dependent RNA polymerase），缩写 RdRp 或 RDR，系一类能以RNA为模板复制RNA的 酶。 值得注意的是，这类酶与以DNA为模板合成RNA的 RNA聚合酶 （在 转录 中扮演重要角色的酶）不是同一类酶。 RNA复制酶对于那些反 义 RNA病毒 （例如 流感病毒）的增殖来说，是一种至关重要的 蛋白质 [2][3]。 RNA复制酶能合成一条RNA单链的互补链 [4][5]。 病毒 RdRps 是在 1960 年代早期通 …

RNA复制酶（RdRp）亦称RNA合成酶，是RNA聚合酶的一种，即“依赖于RNA的RNA聚合酶”（细胞中用来转录的RNA聚合酶全称是“依赖于DNA的RNA聚合酶”），可以以RNA为模板合成RNA。

2021年1月29日 · Remdesivir targets the RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA replication and a promising drug target for COVID-19. Recently, several structures of RdRp in complex with substrate RNA and remdesivir were reported, providing insights into the mechanisms of RNA recognition by RdRp.

RdRP可以通过Dicer依赖和非依赖的两种途径产生SiRNA。 前者是RdRP先合成较长的双链RNA，再被Dicer加工成SiRNA；后者是RdRP直接从头合成SiRNA而无需酶切。

2020年5月15日 · The RNA-dependent RNA polymerase [ (RdRp), also named nsp12] is the central component of coronaviral replication and transcription machinery, and it appears to be a primary target for the antiviral drug remdesivir.

2020年8月17日 · Family Coronaviridae comprises positive, single-stranded RNA viruses that use RNA-dependent RNA polymerase (RdRP) for viral replication and transcription. As the RdRP of viruses in this family and others plays a pivotal role in infection, it is a promising therapeutic target for developing antiviral agents against them.