RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.

研究结论：Rheb泛素化需要TSC复合物的GAP活性，其中TSC2可能主要促进Rheb的单泛素化。另外，Rheb的泛素化与其失活密切相关，而EGF处理会抑制Rheb的泛素化。 2.RNF152是Rheb的E3泛素连接酶. 作者筛选了一组E3连接酶，以确定催化Rheb泛素化的特异性E3连接酶。

2024年12月25日 · RHEB (Ras Homolog, MTORC1 Binding) is a Protein Coding gene. Diseases associated with RHEB include Focal Cortical Dysplasia, Type Ii and Isolated Focal Cortical Dysplasia Type Ii. Among its related pathways are Translation Insulin regulation of translation and PIP3 activates AKT signaling.

2017年12月13日 · Here we present the 3.0 ångström cryo-electron microscopy structure of mTORC1 and the 3.4 ångström structure of activated RHEB–mTORC1. RHEB binds to mTOR distally from the kinase active site,...

RHEB is an important small GTPase that acts as an allosteric activator of the mTORC1 complex, a key nutrient sensor that controls cell growth and biomass production. In response to signals such as nutrients and growth factors, RHEB activates the MTOR kinase within mTORC1 by inducing conformational changes.

Rheb是一种小H-Ras-like GTPase，是溶酶体表面 雷帕霉素 复合物1（mTORC1）机制靶点的直接和必要激活剂。在研究Rheb在突触信号传导和细胞分化中的作用是，发现Rheb与丙酮酸代谢的能量调节中的线粒体调节有关。

12月20日，中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）丁建平研究组在Journal of Molecular Cell Biology发表了题为“Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling”的论文，该研究揭示了Rheb疾病相关突变 ...

2018年2月7日 · Here, we report the discovery of a small molecule (NR1) that binds Rheb in the switch II domain and selectively blocks mTORC1 signaling. NR1 potently inhibits mTORC1 driven phosphorylation of...

大脑中富集的小 GTPase Ras 同系物 (Rheb) 在激活雷帕霉素复合物 1 (mTORC1) 的机制靶标方面起着关键作用，mTORC1 是调节各种细胞功能的信号中枢。 我们最近观察到核 mTORC1 活性，提出了一个有趣的问题，即 Rheb（已知被法呢基化并定位于细胞内膜）如何调节核 mTORC1。

RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia. Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation. miR-199a-3p/5p regulate tumorgenesis via targeting Rheb in non-small cell lung cancer.