2024年12月25日 · RHOH (Ras Homolog Family Member H) is a Protein Coding gene. Diseases associated with RHOH include Epidermodysplasia Verruciformis 4 and T-Cell Immunodeficiency With Epidermodysplasia Verruciformis. Among its related pathways are GPCR Pathway and Signaling by Rho GTPases.

Real Husbands of Hollywood (abbreviated RHOH) is an American reality television parody that originally aired on BET from January 15, 2013, to December 13, 2016. [1] A revival series produced for streaming service BET+ premiered on February 10, 2022.

RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. [5] It is encoded by the gene RHOH .

2016年10月14日 · In this study, we report that RhoH deficiency promotes, and RhoH overexpression reduces, eosinophil differentiation in vitro and in vivo. Moreover, RhoH induces the developmentally important...

As an atypical member of the Rho family small GTPases, RhoH shares less than 50% sequence similarity with other members, and its expression is commonly observed in the haematopoietic lineage. To date, RhoH function was observed in regulating T cell receptor signalling, and less is known in other haematopoietic cells.

2006年10月8日 · RhoH is a hematopoietic-specific, GTPase-deficient member of the Rho GTPase family with unknown physiological function. Here we demonstrate that Rhoh−/− mice have impaired T cell receptor...

2025年1月4日 · RhoH is a key adapter protein that maintains LCK in the inactive state, contributing to the regulation of both pre-TCR and TCR signalling during T-cell development. propose that RhoH functions as a negative regulator for IL3-induced signals through modulation of the JAK-STAT pathway

由该基因编码的蛋白质是三磷酸鸟苷 (GTP) 代谢酶 Ras 超家族的成员。 编码的蛋白质在造血细胞中表达，在那里它作为细胞生长和存活的负调节剂发挥作用。 该基因可能在白血病和淋巴瘤中过度突变或错误表达。 非霍奇金淋巴瘤中的染色体易位发生在该基因座和 3 号染色体上的 B 细胞 CLL/淋巴瘤 6 (BCL6) 之间，导致融合转录物的产生。 5' 非翻译区的可变剪接导致编码相同蛋白质的多个转录变体。 [RefSeq 提供，2013 年 5 月] The protein encoded by this gene is a …

使用 Rhoh-/- 小鼠进行的体内研究表明，对大肠杆菌 (E. coli) 的抗菌防御能力增强。 总的来说，我们的数据揭示了 RHOH 作为肌动球蛋白介导的中性粒细胞效应功能的分子制动的先前未定义的作用，这代表了参与控制抗菌炎症反应强度的细胞内调节轴。

2005年2月15日 · Rho guanosine triphosphatases (GT-Pases) are recognized as critical mediators of signaling pathways regulating actin assembly, migration, proliferation, and survival in hematopoietic cells. Here, we have studied a recently identified hematopoietic-specific Rho …