The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (K ir 1.1) that transports potassium out of cells. It plays an important role in potassium recycling in the thick ascending limb (TAL) and potassium secretion …

肾外髓钾通道(renal outer medullary potassium channel, ROMK)是内向整流钾通道超家族成员,介导肾小管上皮细胞内K+ 向小管腔的转运,在维持机体钾稳态方面发挥重要作用。

The apically located renal outer medullary K + (ROMK) channel provides a pathway for K + to recycle from cell to lumen, and ensures an adequate supply of K + to sustain Na +-K +-2Cl − cotransport. This movement through ROMK creates a lumen-positive voltage, providing a driving force for passive K + reabsorption through the paracellular pathway.

Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.

钾离子（紫色）通过钾离子通道的俯视图（PDB 1BL8）。 在 细胞生物学 的范畴， 钾离子通道 是最广泛分布的 离子通道，且几乎存在大多数的生物中。 [1] 它们具有钾离子选择性的孔洞在 细胞膜 上，并且存在于大多数的 细胞，控制了广泛的生物功能。 [2] [3] 钾离子通道主要有四种分类： 钙激活钾离子通道 (Calcium-activated potassium channel)：当钙离子或其它讯息分子出现时开啓。 内向整流钾离子通道 (Inwardly rectifying potassium channel)：使正电荷（电流）由细胞外向 …

2018年1月14日 · 这个 ROMK，即 the renal outer-medullary K+ channel，是今天要说的一个重要结构，有个很拗口的中文名称：肾脏外髓钾通道。 也有称之为 KIR1.1，学名应该是：potassium voltage-gated channel subfamily J member 1，感兴趣的可以看看这方面更多的文献。

This brief review attempts to provide an overview regarding recent developments in the regulation of ROMK channels. Studies performed in ROMK null mice suggest that ROMK cannot only form hometetramers such as the small-conductance (30-pS) K channels but also construct heterotetramers such as the 70-pS K channel in the thick ascending limb (TAL).

The ability of intracellular and extracellular Mg2+ to block secretory K+ currents through ROMK channels under physiologic conditions is incompletely understood. We expressed ROMK2 channels in Xenopus oocytes and measured unitary currents in the ...

ROMK is a gene encoding inwardly rectifying adenosine triphosphate regulated K+ channels. Alternative splicing of ROMK exons yields several different transcripts, ROMK 1-3, that are differentially expressed along the nephron. Cloned ROMK channels expressed in Xenopus oocytes exhibit properties simil …

In recent years, understanding of the physiological role of the renal outer medullary potassium (ROMK) channels, has shown an intriguing pharmacological target for developing an innovative class of diuretic agents: the ROMK inhibitors.