2024年12月25日 · SIK2 (Salt Inducible Kinase 2) is a Protein Coding gene. Diseases associated with SIK2 include Pancreatic Cancer and Endometrial Cancer. Among its related pathways are Glucose / Energy Metabolism and LKB1 signaling events.

2020年8月12日 · The function of SIK2 and SIK3 in tumorigenesis. SIK2 and SIK3 are regarded as potential oncogenes. SIK2 acts as an activator of PI3K/AKT signal, which promotes the Warburg effect and...

2023年8月15日 · Salt-inducible kinase 2 (SIK2) has been recognized as a potential target for anti-inflammation and anti-cancer therapy. In this paper, based on the binding pose of the reported compound (GLPG-3970, 3) with AlphaFold protein structure, a series of hinge cores were generated via AI-generative models (Chemistry42).

2025年2月9日 · SIK2 represses AKT/GSK3beta/beta-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases. Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human beta cell proliferation.

盐诱导激酶 (salt-inducible kinase,SIK)是属于单磷酸腺苷激活蛋白激酶/蔗糖非酵解1 (adenosine monophosphate—activated protein kinase and sucrose nonfermenting 1,AMPK/SNF1)家族的丝氨酸/苏氨酸蛋白激酶。 SIK自1998年被发现以来,越来越多的功能被人们证实和认可。 现已发现,SIK在能量代谢、细胞信号转导、细胞周期、肿瘤、黑素原生成等诸多方面有重要作用。 通过查阅近些年相关文献,在此重点总结一下SIK2功能的研究进展。 百度学术集成海量学术资源，融合 …

2020年1月28日 · Salt-inducible kinase 2 (SIK2), which belongs to the AMP-activated protein kinase family, modulates various biological functions including fatty acid oxidation. However, the role of SIK2 in glucose metabolism reprogramming remains unclear in ovarian cancer (OC) cells. Here, we found that SIK2 signif …

Salt-inducible kinase 2 (SIK2) belongs to the serine/threonine protein kinases of the AMPK/SNF1 family, which has important roles in cell cycle, tumor, melanogenesis, neuronal damage repair and apoptosis. Recent studies showed that SIK2 regulates the macrophage polarization to make a balance between inflammation and macrophage.

2019年1月21日 · Salt-inducible kinase (SIK), which belongs to the sucrose non-fermenting 1/AMP-activated protein kinase family, was first discovered in the adrenal cortex of a rat on a high-salt diet. As an isoform of the SIK family, SIK2 modulates various biological functions and acts as a signal transmitter in various pathways.

2014年2月23日 · Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in...

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]