2024年12月25日 · Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1.

Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene. [5][6][7][8] SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family. This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex.

该基因编码一种参与无义介导的 mRNA 衰变 (NMD) 的蛋白质，作为 mRNA 监视复合体的一部分。 该蛋白具有激酶活性，被认为通过磷酸化无义转录物调节蛋白 1 在 NMD 中发挥作用。 已经描述了选择性剪接的转录物变体，但它们的全长性质尚未确定。 [RefSeq 提供，2013 年 3 月] This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex.

SuperMemeGuardian1 and SuperMemeGuardian2, abbreviated as SMG1 and SMG2 or colloquially as One and Two, are two of the three overarching protagonists (alongside SMG0) of the SMG4 series.

We show that a novel phosphatidylinositol 3-kinase-related protein kinase, hSMG-1, is a human ortholog of a product of Caenorhabditis elegans smg-1, one of seven smg genes involved in NMD. hSMG-1 phosphorylates hUPF1/SMG-2 in vivo and in vitro at specific serine residues in SQ motifs. hSMG-1 can associate with hUPF1/SMG-2 and other components ...

We report here that smg - 1, which is required for NMD in C. elegans, encodes a protein kinase of the phosphatidylinositol kinase superfamily of protein kinases. We identify null alleles of smg - 1 and demonstrate that SMG-1 kinase activity is required in vivo for NMD and in vitro for SMG-2 phosphorylation.

2025年2月9日 · SMG-1 is a target of the oncomiRs, miR-192 and -215, and that its downregulation is associated with tumor size and serosal invasion of gastric cancer (GC). SMG-1 appears to mediate at least some of the oncogenic function of miR-192 and -215 by participating in epithelial-mesenchymal transition, triggered by activation of the Wnt pathway in GC.

Functional profiling of 141 cancer cell lines revealed inhibition of kinase suppressor of morphogenesis in genitalia 1 (SMG1), a key regulator of the RNA degradation mechanism nonsense-mediated mRNA decay (NMD), as an additional target of CC-115.

2009年5月1日 · SMG-8 and SMG-9 suppress SMG-1 kinase activity in the isolated SMG-1 complex and are involved in NMD in both mammals and nematodes. SMG-8 recruits SMG-1 to the mRNA surveillance complex, and inactivation of SMG-8 induces accumulation of a ribosome:Upf1:eRF1:eRF3:EJC complex on mRNP, which physically bridges the ribosome and EJC through eRF1 ...

【摘 要】SMG-1 (suppressor with morphogenetic effect on genitalia-1,SMG-1)是新发现的磷脂酰肌醇-3-激酶相关激酶 (the phosphoinositide 3-kinase-related kinase,PIKKs)家族成员,因其参与无义介导的mRNA降解 (nonsense-mediated mRNA decay,NMD)途径,在基因毒性应激反应中维持基因组稳定性,并参与细胞 ...