Synapsin I, is the collective name for Synapsin Ia and Synapsin Ib, two nearly identical phosphoproteins that in humans are encoded by the SYN1 gene.

2024年12月25日 · SYN1 (Synapsin I) is a Protein Coding gene. Diseases associated with SYN1 include Intellectual Developmental Disorder, X-Linked 50 and Epilepsy, X-Linked 1, With Variable Learning Disabilities And Behavior Disorders. Among its related pathways are Neurotransmitter release cycle and Sensory processing of sound.

2022年10月30日 · hSyn启动子是人SYN1基因的启动子，SYN1基因表达产生Synapsin1的蛋白，是特异性表达在神经元内的蛋白，因此一般选择hSyn启动子作为神经元的特异性启动子。

Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases.

2025年2月8日 · Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases.

突触蛋白 (Syns) 是与神经元发育和神经递质释放密切相关的磷蛋白。 三个不同的基因 SYN1 、 SYN2 和 SYN3， 具有升高的进化保守性，已被描述为分别编码突触蛋白 I、突触蛋白 II 和突触蛋白 III。 Syns 具有一系列共同特征，但也表现出独特的定位、表达模式、翻译后修饰 (PTM)。 这些特性使其能够与其他突触蛋白、膜和细胞骨架成分相互作用，这对于它们在神经元细胞中正确执行多种功能至关重要。 这些包括控制突触形成和生长、神经元成熟和更新，以及突触小泡动员 …

2024年8月27日 · Clinical resource with information about SYN1, Epilepsy, X-linked 1, with variable learning disabilities and behavior disorders, Intellectual disability, X-linked 50, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

The SYN1 gene encodes synapsin I, a neuronal phosphoprotein associated with the membranes of small synaptic vesicles. Synapsins may play a role in synaptic neurotransmission, neuronal development, synaptogenesis, maintenance of mature synapses, and plasticity (summary by Fassio et al., 2011 ).

Synapsin-I (SYN1) is a presynaptic phosphoprotein crucial for synaptogenesis and synaptic plasticity. Pathogenic SYN1 variants are associated with variable X-linked neurodevelopmental disorders mainly affecting males. In this study, we expand on the ...

Synapsin 1 is a peripheral membrane protein on synaptic vesicles that mediates vesicle binding to the cytoskeleton. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly …