2017年8月8日 · 二苯环丁烯酮（dpc）或二丁基酯角鲨烯酸（sadbe）接触免疫治疗可诱发疣体超敏反应，引起局部免疫应答。 用法为初始每周2次治疗，逐渐减少至每3周一次，持续3~6个月。

Topical immunotherapy with SADBE is widely used in the management of patchy AA and can be considered an effective alternative in resistant AAI, providing visible clinical and trichoscopic improvement in the majority of cases.

Dibutyl squarate (also known as squaric acid dibutyl ester or SADBE) is a chemical compound with the molecular formula C 12 H 18 O 4. It is the dibutyl derivative of squaric acid.

Protocol: Squaric Acid Dibutylester (SADBE) Home Immunotherapy of Common Warts General Information: Squaric acid is an immunotherapy used to treat common warts. This treatment is non-toxic, and easy to use. The treatment activated your immune system to combat the warts and therefore it may cause an allergic reaction , similar to poison oak.

方酸二丁酯（SADBE）是斑秃（AA）免疫治疗中常用的接触敏化剂。 当前推荐的1％-2％SADBE高致敏剂量可导致严重的接触性皮炎，通常会降低患者的依从性。 我们评估了在不致敏的情况下使用0.01％起始浓度的SADBE对AA的改良免疫疗法。 最初使用0.01％SADBE的一两周后，SADBE的浓度逐渐增加至0.025％，0.05％，0.1％，0.25％，0.5％，1％和2％，直到患者在AA处感到瘙痒或红斑为止病变部位。 改良的免疫疗法显示出69.4％（25/36）的缓解率，相当 …

Squaric acid dibutyl ester (SADBE) as topical immunotherapy is a good alternative in patients with refractory alopecia areata. In this study, we aimed to evaluate the effectiveness of SADBE treatment in alopecia areata (AA) and alopecia totalis/alopecia universalis (AT/AU) patients and determine the …

Topical squaric acid dibutylester (SADBE) is a contact sensitizer currently being used in the treatment of alopecia areata. It acts as an ideal immunogen because it is not found in the natural environment and is not mutagenic by the Ames test, unlike other topical sensitizers such as dinitrochlorobenzene. 1

Squaric acid dibutyl ester (SADBE) is a topical immunosensitizer that induces a delayed-type hypersensitivity response and is commonly used in the treatment of verruca vulgaris and alopecia areata. When applied to warts, SADBE is believed to incite a T-cell response and to induce the killing of virally infected cells by cytotoxic lymphocytes.

2020年4月1日 · Since we often accept referrals of patients with severe AA, we have great experience of topical immunotherapy treatment of AA with squaric acid dibutylester (SADBE) for many years. In this study, we have evaluated the effect of topical immunotherapy with SADBE on Japanese AA patients.

2019年10月10日 · SADBE療法とは. 円形脱毛症に対する治療法です。SADBE（squaric acid dibutylester）と呼ばれる化学物質を頭皮に塗ることで人工的にかぶれを起こします (1) 。とても効果が高く、日本皮膚科学会でも強く推奨されています (2) 。またその一方で副作用が少ないた …