SGK1 is considered a canonical factor affecting the expression and signal transduction of multiple genes involved in the genesis and development of many human cancers. Abnormal …

2024年10月1日 · Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase belongs to the AGC (cAMP-dependent, cGMP-dependent, and protein kinase C) family …

2022年5月12日 · SGK1 was initially cloned as a gene transcriptionally stimulated by serum and glucocorticoids in rat mammary tumor cells. It is upregulated in some cancers and …

Expression of the serum- and glucocorticoid-inducible kinase 1 (SGK1) is up-regulated by several types of cell stress, such as ischemia, radiation and hyperosmotic shock.

2022年11月14日 · In the present review, we focus on providing current and in-depth evidence regarding the function of SGK1 in sodium transport, cancer progression, and immune …

SGKs not only regulate cell proliferation and survival, but also play important roles in cancer development via an AKT-independent signalling pathway. 1. Introduction. The …

Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases. Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in …

Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP-PNP. Description: Inhibition of enzyme activity in a biochemical assay.

2023年2月16日 · Inhibition of serum and glucocorticoid regulated kinase-1 (SGK1) is proposed as a novel therapeutic for LQTS. Objective: The study sought to test the efficacy of novel, …

2020年11月22日 · SGK1 appears to promote oncogenic signaling aimed at preserving the survival and fitness of cancer cells. Most importantly, recent investigations have revealed the …