Sic1 - Wikipedia
Sic1, a protein, is a stoichiometric inhibitor [1] of Cdk1-Clb (B-type cyclins) complexes in the budding yeast Saccharomyces cerevisiae. Because B-type cyclin-Cdk1 complexes are the …
SIC1 | SGD - Saccharomyces Genome Database
2011年2月7日 · SIC1 encodes a cyclin-dependent kinase inhibitor (CKI) that regulates the cell cycle at the G1 to S transition by inhibiting the activity of the cyclin-dependent kinase (CDK) …
SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, …
2017年10月13日 · Traversal from G1 to S-phase in cycling cells of budding yeast is dependent on the destruction of the S-phase cyclin/CDK inhibitor SIC1. Genetic data suggest that SIC1 …
SIC1 is ubiquitinated in vitro by a pathway that requires CDC4 ... - PubMed
Traversal from G1 to S-phase in cycling cells of budding yeast is dependent on the destruction of the S-phase cyclin/CDK inhibitor SIC1. Genetic data suggest that SIC1 proteolysis is mediated …
Sic1 - an overview | ScienceDirect Topics
2011年2月7日 · Sic1 is responsible for repressing the activity of Clb cyclin-containing Cdc28 complexes until the cell is prepared to leave G1 and commit to progression through the cell …
The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian …
In Saccharomyces cerevisiae, Sic1, an inhibitor of Cdk (cyclin-dependent kinase), blocks the activity of S-Cdk1 (Cdk1/Clb5,6) kinase that is required for DNA replication. Deletion of Sic1 …
Selective Degradation of Ubiquitinated Sic1 by Purified 26S …
2001年1月5日 · We report that ubiquitinated Sic1 (Ub-Sic1) embedded within inactive S phase cyclin-Cdk (S-Cdk) complexes was rapidly degraded by purified 26S proteasomes, yielding …
Order propensity of an intrinsically disordered protein, the cyclin ...
The yeast protein Sic1 is a central regulatory protein of the yeast cell cycle, acting as inhibitor of the cyclin-dependent protein kinases by forming ternary complexes with kinases and their …
Defining structural domains of an intrinsically disordered protein ...
The cyclin-dependent kinase inhibitor Sic1 is an intrinsically disordered protein (IDP) involved in cell-cycle regulation in the yeast Saccharomyces cerevisiae. Notwithstanding many studies on …
Sic1 as a timer of Clb cyclin waves in the yeast cell cycle--design ...
Sic1 is an intrinsically disordered protein and achieves its inhibitory function by cooperative binding, where different structural regions stretch on the Cdk1/Clb surface. Moreover, Sic1 …