2025年2月13日 · Myofibroblasts have been identified as a significant contributor to this scarring. While the differentiation of fibroblasts into myofibroblasts is well-recognized as essential for wound healing and tissue repair, the mechanisms underlying the macrophage-myofibroblast transition (MMT) remain largely unexplored.

2025年1月29日 · Macrophages play a pivotal role in skin wound healing, with M1(classically activated) and M2 (alternatively activated) macrophages exhibiting distinct but complementary functions.

1 天前 · The demarcation between mouse and human tissue was confirmed by immunostaining for mouse- and human-specific collagen, which revealed boundaries between mouse and human skin (fig. S12A). ... including CD9 + SPP1 + ARG1 + wound healing macrophages, CCR7 + migratory ... Autophagy inhibition facilitates wound closure partially dependent on the YAP ...

5 天之前 · The presence of pro-inflammatory M1 macrophages(CD80 positive cells) that at the wound bed over an extended period is considered an indication of delayed wound healing [34]. Thus, we evaluated the presence of M1 macrophages in the wound site implanted with G1, G2, G3 skin constructs.

2025年2月8日 · Wound healing, a physiological process, involves several different types of cells, from immune cells to non-immune cells, including mesenchymal stromal/stem cells (MSC), and their interactions. Immune cells including macrophages, neutrophils, dendritic cells (DC), innate lymphoid cells (ILC), natural killer (NK) cells, and B and T lymphocytes participate in wound …

4 天之前 · Chronic diabetic wounds are characterized by prolonged inflammation and excessive accumulation of M1 macrophages, which impede the healing process. Therefore, resolving inflammation promptly and transitioning to the proliferative phase are critical steps for effective diabetic wound healing. Exosomes have emerged as a promising therapeutic ...

2025年1月31日 · GelMA/DAS/Exo hydrogel was used as a dressing for wound healing in DSI. (A) Preparation of the lemon exosome hydrogel. (B) The lemon exosome hydrogel promoted diabetic wound healing by regulating macrophage polarization and promoting fibroblast and vascular endothelial cell proliferation

2025年2月1日 · In this paper, we present a nanogel coated with macrophage cell membranes (MCM) to camouflage as macrophages for preventing clearance of the immune system and targeting the inflammatory microenvironment in chronic wound healing (Fig. 1).

2025年1月25日 · In diabetic rat skin wounds, the BNIR system significantly enhanced healing by simultaneously neuro-immuno-regulatory, promoting angiogenesis, scavenging ROS, and facilitating tissue remodeling. This work aims to advance the development of a bionic system for electrosensitive tissue repair.

Macrophages play a critical role in the wound healing process and can differentiate into two distinct phenotypes: the pro-inflammatory M1 phenotype and the anti-inflammatory M2 phenotype. Promoting the transformation of macrophages into the anti-inflammatory M2 phenotype may be a promising approach to enhance clinical outcomes of wound healing [5].