Sox6 appears to have a crucial role in the transcriptional regulation of globin genes, and in directing the terminal differentiation of red blood cells. [10] In addition, SOX6 may have a role in tumor growth of Ewing sarcoma. [11]

2024年12月25日 · SOX6 (SRY-Box Transcription Factor 6) is a Protein Coding gene. Diseases associated with SOX6 include Tolchin-Le Caignec Syndrome and Autism Spectrum Disorder. Among its related pathways are Endochondral ossification …

2025年2月8日 · The SOX6 is a novel tumor-suppressor gene in ESCC development and is a potential prognostic marker in esophageal squamous cell carcinoma. identified SOX5 and SOX6 as the first two SHOX-interacting proteins and have shown that this interaction regulates aggrecan expression, an essential factor in chondrogenesis and skeletal development.

In oligodendrocyte development, the role of Sox6 is similar to that in chondrogenesis. Sox6, together with Sox5, regulates proliferation of oligodendrocyte progenitors and prevents precocious exit from the cell cycle. Their functions are also entwined with those of SoxE proteins.

SOX6 is important for positioning and maturation of cortical interneurons (Connor et al., 1995; Batista-Brito et al., 2009). Sox13 is expressed in a sub-population of post-mitotic differentiating neuronal cells and results obtained by Wang et al. (2005) suggest that this gene may have a role in the specification and/or differentiation of a ...

2020年6月4日 · SOX6 belongs to a family of 20 SRY-related HMG-box-containing (SOX) genes that encode transcription factors controlling cell fate and differentiation in many developmental and adult processes. For SOX6, these processes include, but …

2022年2月5日 · Regulation of Sox6 by miRNAs is important in diverse physiological tissues and organs. Dysregulation of the interplay between miRNAs and Sox6 is an important determinant of various disease conditions and may be actionable for therapeutic purposes.

2021年11月9日 · We demonstrate that Sox6 expression distinguishes ventrally and dorsally biased DA neuron populations in the SNc. The Sox6+ population in the ventral SNc includes an Aldh1a1+ subset and is enriched in gene pathways that underpin vulnerability. Sox6+ neurons project to the dorsal striatum and show activity correlated with acceleration.

2009年8月5日 · We found that the transcription factor SOX6 controls the molecular segregation of dorsal (pallial) from ventral (subpallial) telencephalic progenitors and the differentiation of cortical...

这个基因编码一个Y性别决定区域D亚家族的成员，该家族的特征是具有保守的称为高移动性组盒的DNA结合域以及它们结合DNA次沟的能力。 编码的蛋白质是中枢神经系统正常发育、软骨生成和维持心脏和骨骼肌细胞所需的转录激活因子。 编码的蛋白质与其他家族成员相互作用，以协同激活基因表达。 可变剪接导致多个转录变异体。 [RefSeq,2009年3月提供] Dir./Indir. 该模块正在开发中，请耐心等待我们的数据更新。 Genome sequence of the Brown Norway rat yields insights …