2024年12月25日 · SOX7 (SRY-Box Transcription Factor 7) is a Protein Coding gene. Diseases associated with SOX7 include Coffin-Siris Syndrome 2 and Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome. Among its related pathways are Signaling by WNT and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

SOX7 is a transcription factor that comes from the SRY-related HMG-Box family of transcription factors. These factors play a significant developmental role in regulating processes such as hematopoiesis, vasculogenesis, and cardiogenesis during the development of the embryo.

该基因编码参与胚胎发育调控和细胞命运决定的转录因子 SOX (SRY 相关 HMG 盒) 家族成员。 编码的蛋白质在与其他蛋白质形成蛋白质复合物后可以充当转录调节剂。 该蛋白可能在肿瘤发生中发挥作用。 小鼠中的一种类似蛋白质参与无翼型 MMTV 整合位点家族 (Wnt) 通路的调节。 [RefSeq 提供，2008 年 7 月]

2025年1月4日 · SOX7 is a novel tumor suppressor gene silenced in the majority of NSCLC samples. Sox7 is a negative regulator of Wnt/beta-catenin signaling pathway through impeding the transcriptional machinery of beta-catenin/TCF/LEF-1 transcriptional complex, and the loss of expression may be involved in the pathogenesis of endometrial cancer.

2024年2月9日 · SOX7, as the first direct endothelial-specific regulator of Vegfc transcription, can strictly control the number and spatial distribution of lymphatic endothelial cells (LECs) by locally ...

2001年11月1日 · Transfection experiments done in COS7 cells revealed that the full-length SOX7 (FLSox7) activates transcription by binding to a consensus DNA binding site present in the reporter plasmid SOXLUC, while mutants with deletions of the C-terminal domain of Sox7 failed to function as transcriptional activators (Fig. 5). Transcription activation ...

2021年4月12日 · In summary, our findings identify Sox7 as a novel AVSD pathogenic candidate gene, and it can regulate the EndMT involved in atrioventricular cushion morphogenesis through Wnt4–Bmp2 signaling....

In this review, we introduce SOX7 gene and protein structures, and discuss its expression and functional role in cancer development and progression. SOX7 is frequently downregulated in many human cancers and its reduced expression correlates with …

In this paper, we first review the highly conserved and robust cardiovascular expression pattern of Sox7 across multiple species. We then provide evidence of a compelling role for Sox7 in vascular development, elucidating major pathways in which Sox7 functions, including VEGF/Flk1 signaling, Wnt signaling, and Notch pathway.

2020年4月10日 · Intriguingly, expression of the gene encoding the developmental transcription factor SOX7 (SRY-box transcription factor 7) rapidly and transiently increased during hypoxia. Transcriptomic and functional analyses of ECs following SOX7 depletion established its critical role in regulating hypoxia-induced angiogenesis.