2 天之前 · To compare mammalian cell types with those from another amniote lineage, we generated chicken telencephalon single-cell multiome and spatially resolved transcriptomics [spatial enhanced resolution omics-sequencing (Stereo-seq) and Nova spatial transcriptomics (Nova-ST)] datasets containing 23,179 cells and between 27,487 and 79,104 spatial bins ...

1 天前 · The combined usage of single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics has ushered in a revolutionary era in cancer research, providing an unprecedented avenue to dissect the cellular composition and molecular intricacies of TME with spatially resolved information across a wide range of human malignancies.

2021年1月6日 · Nature Methods has crowned spatially resolved transcriptomics Method of the Year 2020. Starry skies invite space exploration. In transcriptomics, spatial resolution opens up new worlds too....

4 天之前 · “Spatially-resolved transcriptomics”, is often used as an umbrella term for distinct technologies that measure gene expression with spatial resolution. However, due to intrinsic differences in these technologies, for example, sequencing-based versus imaging-based, data generated by these technologies have various resolutions, leading to ...

2025年1月29日 · In this study, we developed and validated a diagnostic application of spatially resolved transcriptomics, offering a computational framework, named NePSTA (neuropathology spatial transcriptomic...

2024年9月3日 · We evaluated the fitness of Spacia for three commercialized single-cell resolution SRT technologies: MERSCOPE/Vizgen, CosMx/NanoString and Xenium/10x. Overall, Spacia represents a notable step in...

2023年9月1日 · In this review, we introduce recent progresses and challenges on SRT from the perspectives of technologies and bioinformatic tools, as well as the representative SRT applications.

In this review, we focus on the current state-of-the-art spatially resolved transcriptomic technologies, describe their applications in a variety of biological domains, and explore recent discoveries demonstrating their enormous potential in biomedical research.

2020年5月4日 · In this review, available spatial transcriptomics methods are described and their applications as well as their strengths and weaknesses are discussed. Future developments are explored and where the field is heading to is deliberated upon.

3 天之前 · Deciphering spatial domains from spatially resolved transcriptomics with an adaptive graph attention auto-encoder. Nat. Commun. 2022; 13, 1739. Crossref. Scopus (225) Google Scholar. 55.