2024年12月25日 · TAL1 (TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor) is a Protein Coding gene. Diseases associated with TAL1 include Precursor T-Cell Acute Lymphoblastic Leukemia and Leukemia, Acute Lymphoblastic. Among its related pathways are Gene expression (Transcription) and Assembly of the pre-replicative complex.

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene. [5] [6] The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. Interactions.

TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in the process of hematopoiesis and leukemogenesis. It participates in blood cell formation, forms mesoderm in early embryogenesis, and regulates hematopoiesis in adult organisms.

2023年5月1日 · T-cell acute lymphocytic leukemia protein 1 (TAL1) is one of the most frequently deregulated oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). Its deregulation can occur through diverse cis-alterations, including SIL-TAL1 microdeletions, translocations with T-cell Receptor loci, and more rec …

We show that TAL1 coordinates expression of genes in most known red cell–specific processes. The majority of TAL1's genomic targets require direct DNA-binding activity. However, one-fifth of TAL1's target sequences, mainly among those showing high affinity for TAL1, can recruit the factor independently of its DNA binding activity.

TAL1/SCL is one of the most prevalent oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). TAL1 and its regulatory partners (GATA3, RUNX1, and MYB) positively regulate each other and coordinately regulate the expression of their downstream target genes in T-ALL cells.

In this review, we focus on the oncogenic transcription factor TAL1 and the tumor-suppressor E-proteins and discuss the malignant cell state, the transcriptional circuit, and the consequence of molecular abnormalities in T-ALL.

TAL1, also known as SCL, is a transcription factor that plays a crucial role in early hematopoiesis. It is expressed in normal erythroid precursors and megakaryocytes, but not in normal T cells. In some cases of pediatric T-ALL, the TAL1 gene is aberrantly expressed due to chromosomal rearrangements or deletions, leading to distinct ...

2023年8月17日 · In this study, we first identify an evolutionarily conserved enhancer element controlling the MYCN oncogene (named enhMYCN) that is aberrantly activated by the TAL1 complex in T-ALL cells....

2022年10月10日 · The transcriptional regulator Tal1 exerts essential functions in the earliest stages of blood development, but is considered dispensable for the EHT.