2024年12月25日 · TCF3 (Transcription Factor 3) is a Protein Coding gene. Diseases associated with TCF3 include Agammaglobulinemia 8A, Autosomal Dominant and Agammaglobulinemia 8B, Autosomal Recessive. Among its related pathways are …

Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. [5] [6] [7] TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression. [8]

转录因子 3： 该基因编码 E 蛋白 (I 类) 螺旋-环-螺旋转录因子家族的成员。 E 蛋白通过以异二聚体或同二聚体的形式与靶基因上的调节性 E-box 序列结合来激活转录，并被 DNA 结合 (IV 类) 螺旋-环-螺旋蛋白抑制剂的异二聚化所抑制。 E 蛋白在淋巴细胞生成中起关键作用，编码的蛋白是 B 和 …

TCF3（Transcription Factor 3）是一个转录因子，它在多种细胞过程中起到关键作用，尤其在胚胎发育和B细胞分化中。 以下是TCF3参与的一些重要的基因调控网络和通路：

2025年1月5日 · Title: Molecular characterization of TCF3::PBX1 chromosomal breakpoints in acute lymphoblastic leukemia and their use for measurable residual disease assessment. Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma.

2021年6月26日 · These findings reveal that TCF3 functions as a tumor suppressor epigenetically silenced by EZH2 and DNMT3B in EC, and support the notion that targeting the EZH2/DNMT3B/TCF3/p21 axis may be a...

2024年6月5日 · Research now shows that mouse oocytes use an unusual chromatin signature to mark regulatory elements, and that the transcription factors TCF3 and TCF12 have a key role.

2014年6月9日 · Here we identify a novel role for Tcf3, an essential transcription factor regulating embryonic and adult skin stem cell functions, as a key effector of epidermal wound repair.

2024年6月9日 · Clinical resource with information about TCF3, A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus., Agammaglobulinemia 8, autosomal dominant, Agammaglobulinemia 8b, autosomal recessive, and available tests.

2023年12月31日 · Transcription factor 3 (TCF3) is a member of the basic Helix - Loop - Helix (bHLH) transcription factor (TF) family and is encoded by the TCF3 gene (also known as E2A). It has been shown that TCF3 functions as a key transcription factor in the pathogenesis of several human cancers and plays an impor …