2024年12月25日 · TJP1 (Tight Junction Protein 1) is a Protein Coding gene. Diseases associated with TJP1 include Arrhythmogenic Right Ventricular Cardiomyopathy and Brain Edema. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Gene expression (Transcription).

Tight junction protein ZO-1 also known as Zonula Occludens-1 (ZO-1), is a 220-kD peripheral membrane protein that is encoded by the TJP1 gene in humans. [5] It belongs to the family of zonula occludens proteins (ZO-1, ZO-2, and ZO-3), which are tight junction -associated proteins and of which, ZO-1 is the first to be cloned.

TJP1, a Membrane-Expressed Protein, is a Potential Therapeutic and Prognostic Target for Lung Cancer. GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression.

2025年2月8日 · Title: TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta. circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy.

2018年10月12日 · Two TJP1 variants were identified, the first being a novel p.S329L mutation in a 55-year-old man with a severely reduced left ventricular ejection fraction, persistent atrial fibrillation, and recurrent ventricular tachycardia.

2024年11月3日 · Go to Variation Viewer for TJP1 variants Summary This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions.

In vitro and in vivo studies have linked down-regulation of the scaffolding protein ZO-1, encoded by the TJP1 gene, to increased tight junction permeability. This has not, however, been tested in vivo.

One of the tight junction proteins, “tight junction protein 1” (TJP1, zonula occludens-1, ZO-1), is responsible for the protein networks between actin and integral tight junction proteins, such as occludin and claudins (13, 14), in the tight junction, as well as cell integrity.

2006年1月24日 · TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed: 7798316, PubMed: 9792688).

2024年5月23日 · TJP1 is a peripheral membrane phosphoprotein expressed in tight junctions of both epithelial and endothelial cells. TJP1 is located on the cytoplasmic membrane surface precisely at sites of cell-cell contact (summary by Willott et al., 1993 ).