While both human and rat PPT-1 produce substance P and neurokinin A, humans produce more neuropeptide K, whereas rats produce more neuropeptide gamma. In cow brains, PPT-1 …

2024年12月25日 · TAC1 (Tachykinin Precursor 1) is a Protein Coding gene. Diseases associated with TAC1 include Vasomotor Rhinitis and Cystitis. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). Gene Ontology (GO) annotations related to this gene include substance P receptor binding.

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2019年1月2日 · Here, we report that tachykinin 1 (Tac1)-expressing glutamatergic neurons in the lateral and ventrolateral periaqueductal gray (l/vlPAG) facilitate the itch-scratching cycle.

2003年9月2日 · Among these, we identified and characterized tac-1 a new member of the TACC (Transforming Acidic Coiled-Coil) family [1]. tac-1 (RNAi) embryos exhibit very short microtubules nucleated from the centrosomes as well as short spindles. TAC-1 is initially enriched at the meiotic spindle poles and is later recruited to the sperm centrosome.

Mammalian tachykinins are derived from three preprotachykinin genes which according to the Human Genome Organization (HUGO) Gene Nomenclature Committee are termed TAC1, TAC3, and TAC4 (Fig. 1). The TAC1 gene (previously known as the PPT-I or PPT-A gene) is coding for substance P, neurokinin A, and its extended forms.

该基因编码速激肽激素家族的四种产物，P 物质和神经激肽 A，以及相关的肽，神经肽 K 和神经肽γ。 这些激素被认为起到神经递质的作用，与神经受体和平滑肌细胞相互作用。 众所周知，它们会引起行为反应并起到血管扩张剂和促分泌剂的作用。 P 物质是一种具有抗菌和抗真菌特性的抗菌肽。 已发现该基因编码不同异构体的多个转录变体。 [RefSeq 提供，2014 年 11 月]

Reitz研究团队近期发现了激活POA区域Tac1神经元可以有效的增强觉醒，对抗内源性以及麻醉诱导的无意识状态，证实了该神经元参与麻醉相关觉醒过程。 研究人员成功构建了可激活（hM3Dq）和抑制（hM4Di）POATac1神经元的小鼠模型(图1A，1B)，腹腔注射氯氮平氧化物（CNO）成功激活了该神经元（图1D和1E）。 运用红外光束系统评估POATac1神经元激活后小鼠的运动能力，观察到激活（hM3Dq）组断裂的红外光束数量明显增加，抑制（hM4Di）组无明 …

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2024年12月18日 · The parasubthalamic nucleus (PSTN), located in the lateral subdivision of the posterior hypothalamus 22, 23, is composed of mostly glutamatergic neurons, some of which express Tachykinin 1 (Tac1), adenylate cyclase-activating polypeptide (Adcyap1) as well as corticotropin-releasing factor (Crh).